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Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

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  • Frances P. Noonan

    (Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University)

  • M. Raza Zaidi

    (Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH)

  • Agnieszka Wolnicka-Glubisz

    (Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University
    Present address: Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, Krakow 30-348, Poland (A.W.-G.).)

  • Miriam R. Anver

    (Pathology/Histotechnology Laboratory, SAIC-Frederick, National Cancer Institute-Frederick)

  • Jesse Bahn

    (Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University)

  • Albert Wielgus

    (Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park
    Present address: Duke Eye Center, 2351 Erwin Road, Durham, North Carolina 27705, USA (A.W.).)

  • Jean Cadet

    (DSM/INAC/SCIB UMR-E 3 CEA/UJF FRE CNRS 3200/Laboratoire 'Lésions des Acides Nucléiques')

  • Thierry Douki

    (DSM/INAC/SCIB UMR-E 3 CEA/UJF FRE CNRS 3200/Laboratoire 'Lésions des Acides Nucléiques')

  • Stephane Mouret

    (DSM/INAC/SCIB UMR-E 3 CEA/UJF FRE CNRS 3200/Laboratoire 'Lésions des Acides Nucléiques'
    Present address: Department of Toxicology and Chemical Risk, Army Institute for Biomedical Research, La Tronche 38700, France (S.M.).)

  • Margaret A. Tucker

    (National Cancer Institute, NIH)

  • Anastas Popratiloff

    (Center for Microscopy and Image Analysis, Office of the Vice-President, The George Washington University)

  • Glenn Merlino

    (Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH)

  • Edward C. De Fabo

    (Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University)

Abstract

Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320–400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280–320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis.

Suggested Citation

  • Frances P. Noonan & M. Raza Zaidi & Agnieszka Wolnicka-Glubisz & Miriam R. Anver & Jesse Bahn & Albert Wielgus & Jean Cadet & Thierry Douki & Stephane Mouret & Margaret A. Tucker & Anastas Popratiloff, 2012. "Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment," Nature Communications, Nature, vol. 3(1), pages 1-10, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1893
    DOI: 10.1038/ncomms1893
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