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Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila

Author

Listed:
  • Yiannis A. Savva

    (Cell Biology and Biochemistry, Brown University)

  • James E.C Jepson

    (Cell Biology and Biochemistry, Brown University
    Present address: Department of Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA.)

  • Asli Sahin

    (Cell Biology and Biochemistry, Brown University)

  • Arthur U. Sugden

    (Cell Biology and Biochemistry, Brown University)

  • Jacquelyn S. Dorsky

    (Cell Biology and Biochemistry, Brown University)

  • Lauren Alpert

    (Brown University)

  • Charles Lawrence

    (Brown University)

  • Robert A. Reenan

    (Cell Biology and Biochemistry, Brown University)

Abstract

Auto-regulatory feedback loops are a common molecular strategy used to optimize protein function. In Drosophila, many messenger RNAs involved in neuro-transmission are re-coded at the RNA level by the RNA-editing enzyme, dADAR, leading to the incorporation of amino acids that are not directly encoded by the genome. dADAR also re-codes its own transcript, but the consequences of this auto-regulation in vivo are unclear. Here we show that hard-wiring or abolishing endogenous dADAR auto-regulation dramatically remodels the landscape of re-coding events in a site-specific manner. These molecular phenotypes correlate with altered localization of dADAR within the nuclear compartment. Furthermore, auto-editing exhibits sexually dimorphic patterns of spatial regulation and can be modified by abiotic environmental factors. Finally, we demonstrate that modifying dAdar auto-editing affects adaptive complex behaviours. Our results reveal the in vivo relevance of auto-regulatory control over post-transcriptional mRNA re-coding events in fine-tuning brain function and organismal behaviour.

Suggested Citation

  • Yiannis A. Savva & James E.C Jepson & Asli Sahin & Arthur U. Sugden & Jacquelyn S. Dorsky & Lauren Alpert & Charles Lawrence & Robert A. Reenan, 2012. "Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila," Nature Communications, Nature, vol. 3(1), pages 1-10, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1789
    DOI: 10.1038/ncomms1789
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