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Intracellular chloride concentration influences the GABAA receptor subunit composition

Author

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  • Francesca Succol

    (The Italian Institute of Technology
    University of Genova)

  • Hubert Fiumelli

    (Center for Psychiatric Neurosciences, CHUV)

  • Fabio Benfenati

    (The Italian Institute of Technology
    University of Genova)

  • Laura Cancedda

    (The Italian Institute of Technology)

  • Andrea Barberis

    (The Italian Institute of Technology)

Abstract

GABAA receptors (GABAARs) exist as different subtype variants showing unique functional properties and defined spatio-temporal expression pattern. The molecular mechanisms underlying the developmental expression of different GABAAR are largely unknown. The intracellular concentration of chloride ([Cl−]i), the main ion permeating through GABAARs, also undergoes considerable changes during maturation, being higher at early neuronal stages with respect to adult neurons. Here we investigate the possibility that [Cl−]i could modulate the sequential expression of specific GABAARs subtypes in primary cerebellar neurons. We show that [Cl−]i regulates the expression of α3-1 and δ-containing GABAA receptors, responsible for phasic and tonic inhibition, respectively. Our findings highlight the role of [Cl−]i in tuning the strength of GABAergic responses by acting as an intracellular messenger.

Suggested Citation

  • Francesca Succol & Hubert Fiumelli & Fabio Benfenati & Laura Cancedda & Andrea Barberis, 2012. "Intracellular chloride concentration influences the GABAA receptor subunit composition," Nature Communications, Nature, vol. 3(1), pages 1-10, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1744
    DOI: 10.1038/ncomms1744
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