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Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs

Author

Listed:
  • Robert W. Buckheit

    (Johns Hopkins University School of Medicine)

  • Tracy G. Allen

    (Johns Hopkins University School of Medicine)

  • Angela Alme

    (Johns Hopkins University School of Medicine)

  • Maria Salgado

    (Johns Hopkins University School of Medicine)

  • Karen A. O'Connell

    (Johns Hopkins University School of Medicine)

  • Sarah Huculak

    (Johns Hopkins University School of Medicine)

  • Oluwaseun Falade-Nwulia

    (Johns Hopkins University School of Medicine)

  • Thomas M. Williams

    (School of Medicine and Tricore Reference Laboratories, University of New Mexico)

  • Joel E. Gallant

    (Johns Hopkins University School of Medicine)

  • Robert F. Siliciano

    (Johns Hopkins University School of Medicine
    Howard Hughes Medical Institute, Johns Hopkins University School of Medicine)

  • Joel N. Blankson

    (Johns Hopkins University School of Medicine)

Abstract

Viremic controllers and elite controllers/suppressors maintain control over HIV-1 replication. Some studies have suggested that control is a result of infection with a defective viral strain, while others suggested host immune factors have a key role. Here we document two HIV-1 transmission pairs: one consisting of a patient with progressive disease and an individual who became an elite suppressor, and the second consisting of a patient with progressive disease and a viremic controller. In contrast to another elite suppressor transmission pair, virus isolated from all patients was fully competent. These data suggest that some viremic controllers and elite suppressors are infected with HIV-1 isolates that replicate vigorously in vitro and are able to cause progressive disease in vivo. These data suggest that host factors have a dominant role in the control of HIV-1 infection, thus it may be possible to control fully pathogenic HIV-1 isolates with therapeutic vaccination.

Suggested Citation

  • Robert W. Buckheit & Tracy G. Allen & Angela Alme & Maria Salgado & Karen A. O'Connell & Sarah Huculak & Oluwaseun Falade-Nwulia & Thomas M. Williams & Joel E. Gallant & Robert F. Siliciano & Joel N. , 2012. "Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairs," Nature Communications, Nature, vol. 3(1), pages 1-10, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1697
    DOI: 10.1038/ncomms1697
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