IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v2y2011i1d10.1038_ncomms1491.html
   My bibliography  Save this article

The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke

Author

Listed:
  • Kazuhiko Nakano

    (Graduate School of Dentistry, Osaka University)

  • Kazuya Hokamura

    (Hamamatsu University School of Medicine)

  • Naho Taniguchi

    (Graduate School of Dentistry, Osaka University)

  • Koichiro Wada

    (Graduate School of Dentistry, Osaka University)

  • Chiho Kudo

    (Graduate School of Dentistry, Osaka University)

  • Ryota Nomura

    (Graduate School of Dentistry, Osaka University)

  • Ayuchi Kojima

    (Graduate School of Dentistry, Osaka University)

  • Shuhei Naka

    (Graduate School of Dentistry, Osaka University)

  • Yoshinori Muranaka

    (Laboratory for Ultrastructure Researches, Hamamatsu University School of Medicine)

  • Min Thura

    (Hamamatsu University School of Medicine)

  • Atsushi Nakajima

    (Yokohama City University School of Medicine)

  • Katsuhiko Masuda

    (Graduate School of Dentistry, Osaka University
    Masuda Dental Clinic)

  • Ichiro Nakagawa

    (Section of Bacterial Pathogenesis, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University)

  • Pietro Speziale

    (University of Pavia)

  • Nobumitsu Shimada

    (Suita Municipal Hospital)

  • Atsuo Amano

    (Graduate School of Dentistry, Osaka University)

  • Yoshinori Kamisaki

    (Graduate School of Dentistry, Osaka University)

  • Tokutaro Tanaka

    (Seirei Hamamatsu General Hospital)

  • Kazuo Umemura

    (Hamamatsu University School of Medicine)

  • Takashi Ooshima

    (Graduate School of Dentistry, Osaka University)

Abstract

Although several risk factors for stroke have been identified, one-third remain unexplained. Here we show that infection with Streptococcus mutans expressing collagen-binding protein (CBP) is a potential risk factor for haemorrhagic stroke. Infection with serotype k S. mutans, but not a standard strain, aggravates cerebral haemorrhage in mice. Serotype k S. mutans accumulates in the damaged, but not the contralateral hemisphere, indicating an interaction of bacteria with injured blood vessels. The most important factor for high-virulence is expression of CBP, which is a common property of most serotype k strains. The detection frequency of CBP-expressing S. mutans in haemorrhagic stroke patients is significantly higher than in control subjects. Strains isolated from haemorrhagic stroke patients aggravate haemorrhage in a mouse model, indicating that they are haemorrhagic stroke-associated. Administration of recombinant CBP causes aggravation of haemorrhage. Our data suggest that CBP of S. mutans is directly involved in haemorrhagic stroke.

Suggested Citation

  • Kazuhiko Nakano & Kazuya Hokamura & Naho Taniguchi & Koichiro Wada & Chiho Kudo & Ryota Nomura & Ayuchi Kojima & Shuhei Naka & Yoshinori Muranaka & Min Thura & Atsushi Nakajima & Katsuhiko Masuda & Ic, 2011. "The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke," Nature Communications, Nature, vol. 2(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1491
    DOI: 10.1038/ncomms1491
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms1491
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms1491?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1491. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.