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A segmental genomic duplication generates a functional intron

Author

Listed:
  • Uffe Hellsten

    (DOE Joint Genome Institute, Walnut Creek, California 94598, USA.)

  • Julie L. Aspden

    (Center for Integrative Genomics, University of California Berkeley, California 94707, USA.
    University of California Berkeley, California 94707, USA.)

  • Donald C. Rio

    (Center for Integrative Genomics, University of California Berkeley, California 94707, USA.
    University of California Berkeley, California 94707, USA.)

  • Daniel S. Rokhsar

    (DOE Joint Genome Institute, Walnut Creek, California 94598, USA.
    Center for Integrative Genomics, University of California Berkeley, California 94707, USA.)

Abstract

An intron is an extended genomic feature whose function requires multiple constrained positions—donor and acceptor splice sites, a branch point, a polypyrimidine tract and suitable splicing enhancers—that may be distributed over hundreds or thousands of nucleotides. New introns are therefore unlikely to emerge by incremental accumulation of functional sub-elements. Here we demonstrate that a functional intron can be created de novo in a single step by a segmental genomic duplication. This experiment recapitulates in vivo the birth of an intron that arose in the ancestral jawed vertebrate lineage nearly half-a-billion years ago.

Suggested Citation

  • Uffe Hellsten & Julie L. Aspden & Donald C. Rio & Daniel S. Rokhsar, 2011. "A segmental genomic duplication generates a functional intron," Nature Communications, Nature, vol. 2(1), pages 1-6, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1461
    DOI: 10.1038/ncomms1461
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