IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v2y2011i1d10.1038_ncomms1426.html
   My bibliography  Save this article

Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche

Author

Listed:
  • Marcus Michel

    (Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Tatzberg 47–49)

  • Isabel Raabe

    (Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Tatzberg 47–49)

  • Adam P. Kupinski

    (Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Tatzberg 47–49)

  • Raquel Pérez-Palencia

    (Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Tatzberg 47–49)

  • Christian Bökel

    (Center for Regenerative Therapies Dresden (CRTD), TU Dresden, Tatzberg 47–49)

Abstract

According to the stem cell niche synapse hypothesis postulated for the mammalian haematopoietic system, spatial specificity of niche signals is maximized by subcellularly restricting signalling to cadherin-based adherens junctions between individual niche and stem cells. However, such a synapse has never been observed directly, in part, because tools to detect active growth factor receptors with subcellular resolution were not available. Here we describe a novel fluorescence-based reporter that directly visualizes bone morphogenetic protein (BMP) receptor activation and show that in the Drosophila testis a BMP niche signal is transmitted preferentially at adherens junctions between hub and germline stem cells, resembling the proposed synapse organization. Ligand secretion involves the exocyst complex and the Rap activator Gef26, both of which are also required for Cadherin trafficking towards adherens junctions. We, therefore, propose that local generation of the BMP signal is achieved through shared use of the Cadherin transport machinery.

Suggested Citation

  • Marcus Michel & Isabel Raabe & Adam P. Kupinski & Raquel Pérez-Palencia & Christian Bökel, 2011. "Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche," Nature Communications, Nature, vol. 2(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1426
    DOI: 10.1038/ncomms1426
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms1426
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms1426?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1426. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.