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Drosophila neuroblasts retain the daughter centrosome

Author

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  • Jens Januschke

    (IRB-Barcelona, Institute for Research in Biomedicine (IRB-Barcelona), Baldiri i Reixac 12, 08028 Barcelona, Spain.)

  • Salud Llamazares

    (IRB-Barcelona, Institute for Research in Biomedicine (IRB-Barcelona), Baldiri i Reixac 12, 08028 Barcelona, Spain.)

  • Jose Reina

    (IRB-Barcelona, Institute for Research in Biomedicine (IRB-Barcelona), Baldiri i Reixac 12, 08028 Barcelona, Spain.)

  • Cayetano Gonzalez

    (IRB-Barcelona, Institute for Research in Biomedicine (IRB-Barcelona), Baldiri i Reixac 12, 08028 Barcelona, Spain.
    Institució Catalana de Recerca i Estudis Avançats, Passeig Lluís Companys 23, 08010 Barcelona, Spain.)

Abstract

During asymmetric mitosis, both in male Drosophila germline stem cells and in mouse embryo neural progenitors, the mother centrosome is retained by the self-renewed cell; hence suggesting that mother centrosome inheritance might contribute to stemness. We test this hypothesis in Drosophila neuroblasts (NBs) tracing photo converted centrioles and a daughter-centriole-specific marker generated by cloning the Drosophila homologue of human Centrobin. Here we show that upon asymmetric mitosis, the mother centrosome is inherited by the differentiating daughter cell. Our results demonstrate maturation-dependent centrosome fate in Drosophila NBs and that the stemness properties of these cells are not linked to mother centrosome inheritance.

Suggested Citation

  • Jens Januschke & Salud Llamazares & Jose Reina & Cayetano Gonzalez, 2011. "Drosophila neuroblasts retain the daughter centrosome," Nature Communications, Nature, vol. 2(1), pages 1-6, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1245
    DOI: 10.1038/ncomms1245
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