IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v2y2011i1d10.1038_ncomms1236.html
   My bibliography  Save this article

Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis

Author

Listed:
  • Shaowei Li

    (Uniformed Services University of the Health Sciences)

  • Rajesh L. Thangapazham

    (Uniformed Services University of the Health Sciences)

  • Ji-an Wang

    (Uniformed Services University of the Health Sciences)

  • Sangeetha Rajesh

    (Uniformed Services University of the Health Sciences)

  • Tzu-Cheg Kao

    (Uniformed Services University of the Health Sciences)

  • Leonard Sperling

    (Uniformed Services University of the Health Sciences)

  • Joel Moss

    (Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Thomas N. Darling

    (Uniformed Services University of the Health Sciences)

Abstract

Hamartomas are composed of cells native to an organ but abnormal in number, arrangement or maturity. In the tuberous sclerosis complex (TSC), hamartomas develop in multiple organs because of mutations in TSC1 or TSC2. Here we show that TSC2-null fibroblast-like cells grown from human TSC skin hamartomas induced normal human keratinocytes to form hair follicles and stimulated hamartomatous changes. Follicles were complete with sebaceous glands, hair shafts and inner and outer root sheaths. TSC2-null cells surrounding the hair bulb expressed markers of the dermal sheath and dermal papilla. Tumour xenografts recapitulated characteristics of TSC skin hamartomas with increased mammalian target of the rapamycin complex 1 (mTORC1) activity, angiogenesis, mononuclear phagocytes and epidermal proliferation. Treatment with an mTORC1 inhibitor normalized these parameters and reduced the number of tumour cells. These studies indicate that TSC2-null cells are the inciting cells for TSC skin hamartomas, and suggest that studies on hamartomas will provide insights into tissue morphogenesis and regeneration.

Suggested Citation

  • Shaowei Li & Rajesh L. Thangapazham & Ji-an Wang & Sangeetha Rajesh & Tzu-Cheg Kao & Leonard Sperling & Joel Moss & Thomas N. Darling, 2011. "Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis," Nature Communications, Nature, vol. 2(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1236
    DOI: 10.1038/ncomms1236
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms1236
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms1236?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1236. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.