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A modern ionotropic glutamate receptor with a K+ selectivity signature sequence

Author

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  • H. Janovjak

    (271 Life Sciences Addition, University of California
    Present address: Institute of Science and Technology Austria, Am Campus 1, Klosterneuburg A-3400, Austria.)

  • G. Sandoz

    (271 Life Sciences Addition, University of California
    Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, and Université de Nice Sophia-Antipolis, Sophia-Antipolis)

  • E. Y. Isacoff

    (271 Life Sciences Addition, University of California
    Lawrence Berkeley National Laboratory)

Abstract

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and gates non-selective cation channels. The origins of glutamate receptors are not well understood as they differ structurally and functionally from simple bacterial ligand-gated ion channels. Here we report the discovery of an ionotropic glutamate receptor that combines the typical eukaryotic domain architecture with the 'TXVGYG' signature sequence of the selectivity filter found in K+ channels. This receptor exhibits functional properties intermediate between bacterial and eukaryotic glutamate-gated ion channels, suggesting a link in the evolution of ionotropic glutamate receptors.

Suggested Citation

  • H. Janovjak & G. Sandoz & E. Y. Isacoff, 2011. "A modern ionotropic glutamate receptor with a K+ selectivity signature sequence," Nature Communications, Nature, vol. 2(1), pages 1-5, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1231
    DOI: 10.1038/ncomms1231
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