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B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection

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Listed:
  • Kuan-Hsiang G. Huang

    (Oxford Martin School, Peter Medawar Building for Pathogen Research, University of Oxford)

  • David Bonsall

    (Jefferiss Research laboratories, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place)

  • Aris Katzourakis

    (University of Oxford)

  • Emma C. Thomson

    (Jefferiss Research laboratories, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place)

  • Sarah J. Fidler

    (Jefferiss Research laboratories, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place)

  • Janice Main

    (Jefferiss Research laboratories, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place)

  • David Muir

    (Jefferiss Research laboratories, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place)

  • Jonathan N. Weber

    (Jefferiss Research laboratories, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place)

  • Alexander J. Frater

    (Oxford Martin School, Peter Medawar Building for Pathogen Research, University of Oxford)

  • Rodney E. Phillips

    (Oxford Martin School, Peter Medawar Building for Pathogen Research, University of Oxford)

  • Oliver G. Pybus

    (University of Oxford)

  • Philip J.R. Goulder

    (Oxford Martin School, Peter Medawar Building for Pathogen Research, University of Oxford)

  • Myra O. McClure

    (Jefferiss Research laboratories, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place)

  • Graham S. Cooke

    (Jefferiss Research laboratories, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place)

  • Paul Klenerman

    (Oxford Martin School, Peter Medawar Building for Pathogen Research, University of Oxford)

Abstract

HIV can be partially contained by host immunity and understanding the basis of this may inform vaccine design. The importance of B-cell function in long-term control is poorly understood. One method of investigating this is in vivo cellular depletion. In this study, we take advantage of a unique opportunity to investigate the role of B cells in an HIV-infected patient. The HIV-1+ patient studied here was not taking antiretroviral drugs and was treated for pre-existing low-grade lymphoplasmacytoid lymphoma by depletion of CD20+ B cells using rituximab. We demonstrate that B-cell depletion results in a decline in autologous neutralizing antibody (NAb) responses and a 1.7 log10 rise in HIV-1 plasma viral load (pVL). The recovery of NAbs results in a decline in pVL. The HIV-1 sequences diversify and NAb-resistant mutants are subsequently selected. These data suggest that B-cell function can contribute to the long-term control of pVL, and that NAbs may be more important in controlling chronic HIV-1 infection than previously suspected.

Suggested Citation

  • Kuan-Hsiang G. Huang & David Bonsall & Aris Katzourakis & Emma C. Thomson & Sarah J. Fidler & Janice Main & David Muir & Jonathan N. Weber & Alexander J. Frater & Rodney E. Phillips & Oliver G. Pybus , 2010. "B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection," Nature Communications, Nature, vol. 1(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:1:y:2010:i:1:d:10.1038_ncomms1100
    DOI: 10.1038/ncomms1100
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