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G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion

Author

Listed:
  • Juan Zhang

    (The Joint Laboratory of Apoptosis and Cancer Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences)

  • Weihua Liu

    (The Joint Laboratory of Apoptosis and Cancer Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences)

  • Jianchao Liu

    (College of Life Sciences, Nankai University)

  • Weiming Xiao

    (The Joint Laboratory of Apoptosis and Cancer Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences
    The State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Lei Liu

    (The Joint Laboratory of Apoptosis and Cancer Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences)

  • Chunsun Jiang

    (The Joint Laboratory of Apoptosis and Cancer Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences)

  • Xin Sun

    (The Joint Laboratory of Apoptosis and Cancer Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences)

  • Pingsheng Liu

    (Institute of Biophysics, Chinese Academy of Sciences)

  • Yushan Zhu

    (The Joint Laboratory of Apoptosis and Cancer Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences
    College of Life Sciences, Nankai University)

  • Chuanmao Zhang

    (The State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Quan Chen

    (The Joint Laboratory of Apoptosis and Cancer Biology, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences
    College of Life Sciences, Nankai University)

Abstract

Mitofusins (Mfns) mediate the fusion of mitochondrial membranes. However, little is known about how Mfns are regulated to control mitochondrial fusion, which is a multistep process requiring tethering and docking of the outer membranes of two mitochondria. In this study, we report that guanine nucleotide binding protein-β subunit 2 (Gβ2), a WD40 repeats protein and a member of the β-subunits of the heterotrimeric G proteins, has a crucial function in mitochondrial fusion. Gβ2 was found to be enriched on the surface of mitochondria and interacted with mitofusin 1 (Mfn1) specifically. Gβ2 also regulated the mobility of Mfn1 on the surface of the mitochondrial membrane and affected the mitochondrial fusion. Depletion of endogenous Gβ2 resulted in mitochondrial fragmentation, which could be rescued by exogenous Gβ2. These findings have thus uncovered a novel role of Gβ2 in regulating mitochondrial fusion through its interaction with Mfn1.

Suggested Citation

  • Juan Zhang & Weihua Liu & Jianchao Liu & Weiming Xiao & Lei Liu & Chunsun Jiang & Xin Sun & Pingsheng Liu & Yushan Zhu & Chuanmao Zhang & Quan Chen, 2010. "G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion," Nature Communications, Nature, vol. 1(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:1:y:2010:i:1:d:10.1038_ncomms1099
    DOI: 10.1038/ncomms1099
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