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Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics

Author

Listed:
  • Ashley W. Seifert

    (University of Florida)

  • Zhengui Zheng

    (Howard Hughes Medical Institute, University of Florida
    University of Florida)

  • Brandi K. Ormerod

    (University of Florida)

  • Martin J. Cohn

    (University of Florida
    Howard Hughes Medical Institute, University of Florida
    University of Florida)

Abstract

The faithful positioning and growth of cells during embryonic development is essential. In this study Seifertet al. demonstrate that inactivation of Sonic Hedgehogduring development of the genital tubercle results in a prolonged G1 phase and a slower rate of growth.

Suggested Citation

  • Ashley W. Seifert & Zhengui Zheng & Brandi K. Ormerod & Martin J. Cohn, 2010. "Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics," Nature Communications, Nature, vol. 1(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:1:y:2010:i:1:d:10.1038_ncomms1020
    DOI: 10.1038/ncomms1020
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