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Drug-tolerant persister cells in cancer: bridging the gaps between bench and bedside

Author

Listed:
  • Zhile Wang

    (Sichuan University)

  • Mengyao Wang

    (Sichuan University)

  • Bo Dong

    (Southern Medical University)

  • Yuqing Wang

    (Sichuan University)

  • Zheyu Ding

    (Sichuan University)

  • Shensi Shen

    (Sichuan University)

Abstract

Drug-tolerant persister (DTP) cells represent a major obstacle to achieving durable cancer remission, yet their biology and clinical relevance remain poorly understood. This perspective highlights key gaps hindering the translation of DTP research into clinical progress, emphasizing the need to move beyond reductionist models toward integrative, patient-aligned approaches that reflect clinical complexity. Bridging these divides will be crucial to reveal actionable biomarkers and develop therapies capable of eradicating these resilient cell populations.

Suggested Citation

  • Zhile Wang & Mengyao Wang & Bo Dong & Yuqing Wang & Zheyu Ding & Shensi Shen, 2025. "Drug-tolerant persister cells in cancer: bridging the gaps between bench and bedside," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-66376-6
    DOI: 10.1038/s41467-025-66376-6
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    References listed on IDEAS

    as
    1. Shensi Shen & Sara Faouzi & Amandine Bastide & Sylvain Martineau & Hélène Malka-Mahieu & Yu Fu & Xiaoxiao Sun & Christine Mateus & Emilie Routier & Severine Roy & Laurent Desaubry & Fabrice André & Al, 2019. "An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    2. Guillaume Harmange & Raúl A. Reyes Hueros & Dylan L. Schaff & Benjamin Emert & Michael Saint-Antoine & Laura C. Kim & Zijian Niu & Shivani Nellore & Mitchell E. Fane & Gretchen M. Alicea & Ashani T. W, 2023. "Disrupting cellular memory to overcome drug resistance," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
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