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Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic

Author

Listed:
  • Samantha J. Bents

    (Stanford University, Division of Infectious Diseases and Geographic Medicine, Department of Medicine
    National Institutes of Health, Fogarty International Center)

  • Emily T. Martin

    (University of Michigan School of Public Health, Department of Epidemiology)

  • Terry Stevens-Ayers

    (Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division)

  • Claire Andrews

    (Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division)

  • Amanda Adler

    (Seattle Children’s Hospital, Division of Pediatric Infectious Diseases)

  • Amanda C. Perofsky

    (National Institutes of Health, Fogarty International Center
    University of Washington, Brotman Baty Institute)

  • Elizabeth M. Krantz

    (Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division)

  • Rachel Blazevic

    (Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division)

  • Louise Kimball

    (Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division)

  • Robin Prentice

    (Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division)

  • Chelsea Hansen

    (National Institutes of Health, Fogarty International Center
    University of Washington, Brotman Baty Institute)

  • Lea Starita

    (University of Washington, Brotman Baty Institute)

  • Peter Han

    (University of Washington, Brotman Baty Institute)

  • Janet A. Englund

    (University of Washington, Division of Pediatric Infectious Diseases, Department of Pediatrics)

  • Nicole Wolter

    (National Institute for Communicable Diseases of the National Health Laboratory Service, Centre for Respiratory Diseases and Meningitis
    University of the Witwatersrand, School of Pathology, Faculty of Health Sciences)

  • Anne von Gottberg

    (National Institute for Communicable Diseases of the National Health Laboratory Service, Centre for Respiratory Diseases and Meningitis
    University of the Witwatersrand, School of Pathology, Faculty of Health Sciences)

  • Lorens Maake

    (National Institute for Communicable Diseases of the National Health Laboratory Service, Centre for Respiratory Diseases and Meningitis
    University of Witwatersrand, School of Public Health, Faculty of Health Sciences)

  • Jocelyn Moyes

    (National Institute for Communicable Diseases of the National Health Laboratory Service, Centre for Respiratory Diseases and Meningitis
    University of Witwatersrand, School of Public Health, Faculty of Health Sciences)

  • Cheryl Cohen

    (National Institute for Communicable Diseases of the National Health Laboratory Service, Centre for Respiratory Diseases and Meningitis
    University of Witwatersrand, School of Public Health, Faculty of Health Sciences)

  • Michael Boeckh

    (Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division)

  • James A. Hay

    (University of Oxford, Pandemic Sciences Institute, Nuffield Department of Medicine)

  • Alpana Waghmare

    (Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division
    University of Washington, Brotman Baty Institute)

  • Cécile Viboud

    (National Institutes of Health, Fogarty International Center)

Abstract

The rebound of endemic respiratory viruses following the COVID-19 pandemic was marked by atypical transmission dynamics, with children experiencing increased disease burden and out-of-season epidemics as restrictions relaxed. Here we used serology from a newly developed quantitative multiplex assay to assess the post-pandemic immunity debt. We assessed age-specific antibody dynamics across a broad range of respiratory viruses, including influenza, respiratory syncytial virus, seasonal coronaviruses, and SARS-CoV-2 using serology collected in King County, Washington, US, from 2020-2022 (n = 1508). We found that respiratory virus immunodynamics differed between individuals

Suggested Citation

  • Samantha J. Bents & Emily T. Martin & Terry Stevens-Ayers & Claire Andrews & Amanda Adler & Amanda C. Perofsky & Elizabeth M. Krantz & Rachel Blazevic & Louise Kimball & Robin Prentice & Chelsea Hanse, 2025. "Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-65957-9
    DOI: 10.1038/s41467-025-65957-9
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