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MicroRNA-mediated metabolic disruption as an emerging driver of alcohol use disorder

Author

Listed:
  • Colin J. McArdle

    (Wake Forest University School of Medicine)

  • Kimberly F. Raab-Graham

    (Wake Forest University School of Medicine)

Abstract

Previous research has sought to determine the underlying mechanisms that govern the development of Alcohol Use Disorder (AUD). In a recent study by Ehinger et al., excessive alcohol consumption utilizes mTORC1’s under characterized role in repressing mRNA translation through the upregulation of microRNAs, specifically in a D1-circuit-specific manner, resulting in repression of glycolysis in the brain’s reward pathway.

Suggested Citation

  • Colin J. McArdle & Kimberly F. Raab-Graham, 2025. "MicroRNA-mediated metabolic disruption as an emerging driver of alcohol use disorder," Nature Communications, Nature, vol. 16(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-65743-7
    DOI: 10.1038/s41467-025-65743-7
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    References listed on IDEAS

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    1. Yann Ehinger & Sophie Laguesse & Khanhky Phamluong & Alexandra Salvi & Yoshitaka J. Sei & Zachary W. Hoisington & Drishti Soneja & Sowmya Gunasekaran & Ken Nakamura & Dorit Ron, 2025. "Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Male Mice Consuming Alcohol Attenuates Glycolysis," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
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