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Microengineered patient-derived endometrium-on-a-chip for the evaluation of endometrial receptivity and personalised translational medicine

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  • Gaeun Lee

    (Graduate School, CHA University, Department of Life Science
    Institute of Quantum Biophysics, Sungkyunkwan University, Department of Biophysics
    Sungkyunkwan University, Department of MetaBioHealth)

  • Yu-Gyeong Lee

    (Graduate School, CHA University, Department of Life Science)

  • Hwa Seon Koo

    (CHA Fertility Center Bundang
    Best of ME Fertility Clinic)

  • Sun-Young Hwang

    (Graduate School, CHA University, Department of Life Science)

  • Danbi Lee

    (Graduate School, CHA University, Department of Life Science)

  • Jungseub Lee

    (Seoul National University, Department of Mechanical and Aerospace Engineering)

  • Won Jong Yu

    (Sungkyunkwan University, Department of MetaBioHealth)

  • Yoon Young Kim

    (Seoul National University Hospital, Department of Obstetrics and Gynecology
    Seoul National University, Institute of Reproductive Medicine and Population, Medical Research Center)

  • Seung-Yup Ku

    (Seoul National University Hospital, Department of Obstetrics and Gynecology
    Seoul National University, Institute of Reproductive Medicine and Population, Medical Research Center)

  • Jong-Chan Park

    (Institute of Quantum Biophysics, Sungkyunkwan University, Department of Biophysics
    Sungkyunkwan University, Department of MetaBioHealth
    Sungkyunkwan University, Department of Biopharmaceutical Convergence)

  • Jungho Ahn

    (Institute of Quantum Biophysics, Sungkyunkwan University, Department of Biophysics
    Sungkyunkwan University, Department of MetaBioHealth
    School of Medicine, CHA University, Department of Biochemistry, Research Institute for Basic Medical Science
    School of Medicine, CHA University, Department of Microbiology, Research Institute for Basic Medical Science)

  • Youn-Jung Kang

    (School of Medicine, CHA University, Department of Biochemistry, Research Institute for Basic Medical Science)

Abstract

Endometrial receptivity is a critical determinant of embryo implantation and early pregnancy success; however, current methods for assessing endometrial receptivity remain poorly validated and insufficiently reliable for clinical application. Here, we establish a patient-derived vascularised endometrium-on-a-chip (EoC), successfully replicating the dynamic microenvironment and both temporal and spatial architecture of native endometrial tissue. Using our EoC, we develop a clinically relevant endometrial receptivity scoring system, ERS2, which integrates molecular profiling of established receptivity markers with quantitative analyses of angiogenesis. The ERS2 enables personalised assessment of endometrial health and implantation potential, addressing inter-patient variability often overlooked by conventional techniques. By leveraging our EoC to therapeutic monitoring, we observe progressive restoration of the endometrial microenvironment following platelet-rich-plasma treatments, highlighting the translational utility of our model. This study represents the innovative application of a patient-derived EoC and scoring system to assess receptivity, offering personalised infertility management and advancing targeted therapies in reproductive medicine.

Suggested Citation

  • Gaeun Lee & Yu-Gyeong Lee & Hwa Seon Koo & Sun-Young Hwang & Danbi Lee & Jungseub Lee & Won Jong Yu & Yoon Young Kim & Seung-Yup Ku & Jong-Chan Park & Jungho Ahn & Youn-Jung Kang, 2025. "Microengineered patient-derived endometrium-on-a-chip for the evaluation of endometrial receptivity and personalised translational medicine," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-65406-7
    DOI: 10.1038/s41467-025-65406-7
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