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A systematic review and meta-analysis of the impact of vaccination on prevention of long COVID

Author

Listed:
  • Rhiannon Green

    (Maverex Ltd)

  • Zoe Marjenberg

    (Maverex Ltd)

  • Gregory Y. H. Lip

    (Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool Centre for Cardiovascular Science at University of Liverpool
    Aalborg University, Danish Center for Health Services Research, Department of Clinical Medicine)

  • Amitava Banerjee

    (University College London, Institute of Health Informatics
    Barts Health NHS Trust, Department of Cardiology)

  • Juan Wisnivesky

    (Icahn School of Medicine at Mount Sinai, Division of General Internal Medicine)

  • Brendan C. Delaney

    (Imperial College London, Department of Surgery and Cancer)

  • Michael J. Peluso

    (San Francisco, Division of HIV, Infectious Diseases, and Global Medicine, University of California)

  • Elke Wynberg

    (Mahidol University, Mahidol-Oxford Tropical Medicine Research Unit (MORU))

  • Sultan Abduljawad

    (BioNTech UK Ltd.)

Abstract

Long COVID affects millions worldwide and its prevention is a critical public health strategy. While prior analyses show primary vaccination prevents long COVID in subsequent infections, the effect of booster vaccination on long COVID after Omicron infections is unclear. This systematic review identifies 31 observational studies, of which 11 are suitable for pairwise meta-analyses. The pooled odds ratio (OR) of long COVID in those vaccinated (any dose) versus unvaccinated is 0.77 (95% confidence interval [CI] 0.70–0.85; p

Suggested Citation

  • Rhiannon Green & Zoe Marjenberg & Gregory Y. H. Lip & Amitava Banerjee & Juan Wisnivesky & Brendan C. Delaney & Michael J. Peluso & Elke Wynberg & Sultan Abduljawad, 2025. "A systematic review and meta-analysis of the impact of vaccination on prevention of long COVID," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-65302-0
    DOI: 10.1038/s41467-025-65302-0
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