IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-65028-z.html
   My bibliography  Save this article

Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults

Author

Listed:
  • Maggie A. Stanislawski

    (University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine)

  • Elizabeth Litkowski

    (University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine
    University of Michigan, Department of Neurology, Michigan Medicine)

  • Christopher H. Arehart

    (University of Colorado, Interdisciplinary Quantitative Biology Program
    University of Colorado, Department of Ecology and Evolutionary Biology
    University of Colorado, Institute for Behavioral Genetics)

  • Kai Luo

    (Albert Einstein College of Medicine, Department of Epidemiology and Population Health)

  • Niles Gilmore

    (University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine)

  • Leslie A. Lange

    (University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine
    University of Colorado Anschutz Medical Campus, Department of Epidemiology, School of Public Health)

  • Ethan M. Lange

    (University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine)

  • Kathleen Barnes

    (University of Colorado Anschutz, Department of Biomedical Informatics, School of Medicine)

  • Christy L. Avery

    (University of North Carolina, Department of Epidemiology, Gillings School of Global Public Health)

  • Katie A. Meyer

    (University of North Carolina, Department of Nutrition, Gillings School of Global Public Health)

  • Fernando Holguin

    (University of Colorado Anschutz, Department of Medicine, School of Medicine)

  • Kari E. North

    (The University of Texas Health Science Center, Epidemiology, School of Public Health
    The University of Texas Health Science Center at Houston, Medicine, McGovern Medical School
    Border Health Research Center)

  • Robert D. Burk

    (Albert Einstein College of Medicine, Department of Epidemiology and Population Health
    Albert Einstein College of Medicine, Department of Pediatrics
    Albert Einstein College of Medicine, Department of Microbiology & Immunology)

  • Robert C. Kaplan

    (Albert Einstein College of Medicine, Department of Epidemiology and Population Health)

Abstract

Asthma is a heterogeneous condition that is often comorbid with obesity and influenced by diverse risk factors. Elucidating the association of gut microbial characteristics with asthma could improve our understanding of the pathophysiology. Here, we investigate relationships of host genetics and stool microbiota characteristics with asthma among US Hispanic/Latino adults, while considering the influence of obesity status, using host whole genome sequencing and stool shotgun metagenomic microbiota data from participants of the Hispanic Community Health Study/Study of Latinos. We evaluate cross-sectional associations of microbiota characteristics with asthma and analyse whether they are modified by obesity status (body mass index≥30 kg/m2). We assess differences in alpha diversity, beta diversity, and taxonomic abundance with asthma, independent of obesity, and interactions between asthma and obesity using covariate-adjusted regression-based methods. We generate an asthma polygenic risk score (PRS) and compare the classification accuracy of genetic and microbial factors for asthma status. We report that asthma is associated with differences in overall taxonomic composition (beta diversity; p = 0.001), which is not dependent on obesity status (p = 0.31). Asthma is not associated with alpha diversity metrics (p > 0.17), though obesity is associated with lower alpha diversity (p

Suggested Citation

  • Maggie A. Stanislawski & Elizabeth Litkowski & Christopher H. Arehart & Kai Luo & Niles Gilmore & Leslie A. Lange & Ethan M. Lange & Kathleen Barnes & Christy L. Avery & Katie A. Meyer & Fernando Holg, 2025. "Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-65028-z
    DOI: 10.1038/s41467-025-65028-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-65028-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-65028-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-65028-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.