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Stage-dependent cerebrocerebellar communication during sensorimotor processing

Author

Listed:
  • Vincenzo Romano

    (Erasmus MC)

  • Matthijs Driessche

    (Erasmus MC)

  • Nathalie Wingerden

    (Erasmus MC)

  • Staf Bauer

    (Erasmus MC)

  • Brendan Boeser

    (Erasmus MC)

  • Jorge F. Mejias

    (University of Amsterdam)

  • Chris I. Zeeuw

    (Erasmus MC
    Royal Dutch Academy of Arts & Sciences)

Abstract

Cerebral cortex and cerebellum are essential for sensorimotor control, but the dynamics of their interactions remain unclear. Here, we investigated which pathways prevail during preparation and execution of spontaneous whisker movements in mice. During preparation, neuronal activity of primary motor (M1) and somatosensory (S1) cortex precede that of cerebellar crus regions, with a lead that is consistent with relaying a copy of motor commands. After movement onset, the phase of the signal inverts, indicating a dominant vector signaling from cerebellum to cerebrum. At this stage, Purkinje cell activity correlates more with S1 than M1, generating a prediction of sensory consequences during motor actions. A computational cerebello-cortical model could replicate the changes in dynamics and directionality. Optogenetic manipulations of pons and thalamus confirm the modeled predictions on stage-dependent dynamics. Together our data point towards a swap in direction of information flow between cerebrum and cerebellum when motor preparation switches to execution.

Suggested Citation

  • Vincenzo Romano & Matthijs Driessche & Nathalie Wingerden & Staf Bauer & Brendan Boeser & Jorge F. Mejias & Chris I. Zeeuw, 2025. "Stage-dependent cerebrocerebellar communication during sensorimotor processing," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64592-8
    DOI: 10.1038/s41467-025-64592-8
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