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Zinc finger domains bind low-complexity domain polymers

Author

Listed:
  • Naohiko Iguchi

    (Nara Medical University)

  • Noriyoshi Isozumi

    (Nara Medical University)

  • Yoshikazu Hattori

    (Tokushima University)

  • Tomohiro Imamura

    (Ishikawa Prefectural University)

  • Takeshi Yokoyama

    (Tohoku University
    Tohoku University)

  • Masatomo So

    (Nara Medical University)

  • Hitoki Nanaura

    (Nara Medical University)

  • Takao Kiriyama

    (Nara Medical University)

  • Nobuyuki Eura

    (Nara Medical University)

  • Minako Yamaoka

    (Nara Medical University)

  • Naoki Iwasa

    (Nara Medical University)

  • Tomo Shiota

    (Nara Medical University)

  • Mari Nakanishi

    (Nara Medical University
    Nara Medical University)

  • Nanako Konishi

    (Nara Medical University)

  • Haruka Ito

    (Nara Medical University)

  • Akihito Takeuchi

    (Nara Medical University)

  • Masashi Mori

    (Ishikawa Prefectural University)

  • Shinya Ohki

    (Japan Advanced Institute of Science and Technology (JAIST))

  • Hiroyuki Kumeta

    (Hokkaido University)

  • Hironori Koga

    (Ishikawa Prefectural University)

  • Mai Watabe

    (Tohoku University)

  • Takuya Mabuchi

    (Tohoku University
    Tohoku University)

  • Shingo Kanemura

    (Tohoku University)

  • Masaki Okumura

    (Tohoku University)

  • Yoshikazu Tanaka

    (Tohoku University
    Tohoku University)

  • Ken Morishima

    (Kyoto University)

  • Masaaki Sugiyama

    (Kyoto University)

  • Fumika Ide

    (Ritsumeikan University)

  • Hiroyoshi Matsumura

    (Ritsumeikan University)

  • Takuya Yoshizawa

    (Ritsumeikan University)

  • Ichiro Ota

    (Kindai University Nara Hospital)

  • Naoki Suzuki

    (Tohoku University Graduate School of Medicine)

  • Masashi Aoki

    (Tohoku University Graduate School of Medicine)

  • Yoshito Yamashiro

    (National Cerebral and Cardiovascular Center Research Institute)

  • Tomohide Saio

    (Tokushima University
    Tohoku University
    Kyoto University)

  • Kazuma Sugie

    (Nara Medical University
    Nara Medical University)

  • Eiichiro Mori

    (Nara Medical University
    Nara Medical University)

Abstract

Self-association of low-complexity protein sequences (LC domains) is important for polymer formation. Several molecular chaperones are involved in the regulation of LC domain polymer formation. However, the mechanisms underlying cell recognition of LC domain polymers remain unclear. Here we show that zinc finger domains (ZnFs) bind LC domains of RNA-binding proteins in a cross-β polymer-dependent manner. ZnFs bound to LC domain hydrogels and suppressed LC domain polymer formation. Moreover, ZnFs preferentially recognize LC domains in the polymeric state. These findings suggest that ZnFs act as physiological regulators of LC domain polymer formation.

Suggested Citation

  • Naohiko Iguchi & Noriyoshi Isozumi & Yoshikazu Hattori & Tomohiro Imamura & Takeshi Yokoyama & Masatomo So & Hitoki Nanaura & Takao Kiriyama & Nobuyuki Eura & Minako Yamaoka & Naoki Iwasa & Tomo Shiot, 2025. "Zinc finger domains bind low-complexity domain polymers," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64382-2
    DOI: 10.1038/s41467-025-64382-2
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    References listed on IDEAS

    as
    1. Rajesh Sharma & Kyoung-Jae Choi & My Diem Quan & Sonum Sharma & Banumathi Sankaran & Hyekyung Park & Anel LaGrone & Jean J. Kim & Kevin R. MacKenzie & Allan Chris M. Ferreon & Choel Kim & Josephine C., 2021. "Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
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