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A US case-control study to estimate infant group B streptococcal disease serological thresholds of risk-reduction

Author

Listed:
  • Julia C. Rhodes

    (Centers for Disease Control and Prevention)

  • Rebecca Kahn

    (Centers for Disease Control and Prevention
    Centers for Disease Control and Prevention)

  • Shanna Bolcen

    (Centers for Disease Control and Prevention)

  • Nong Shang

    (Centers for Disease Control and Prevention)

  • Yunmi Chung

    (Centers for Disease Control and Prevention)

  • Monica M. Farley

    (Emory University School of Medicine)

  • Amber N. Britton

    (Emory University School of Medicine)

  • Ashley E. Moore

    (Georgia Department of Public Health)

  • Stepy Thomas

    (Emory University School of Medicine)

  • Joelle Nadle

    (California Emerging Infections Program)

  • Laura B. Amsden

    (Kaiser Permanente Northern California)

  • Jacek Skarbinski

    (Kaiser Permanente Northern California)

  • Kristi R. VanWinden

    (San Leandro)

  • Meghan Barnes

    (Colorado Department of Public Health and Environment)

  • Kerianne Engesser

    (New York State Department of Health)

  • Patricia Ferrieri

    (University of Minnesota Medical School)

  • AmberJean P. Hansen

    (Connecticut Emerging Infections Program)

  • Lee H. Harrison

    (Johns Hopkins Bloomberg School of Public Health)

  • Laura Jeffrey

    (Johns Hopkins Bloomberg School of Public Health)

  • Jessica L. Nyholm

    (University of Minnesota Medical School)

  • Sean T. O’Leary

    (University of Colorado School of Medicine)

  • Courtney Olson-Chen

    (University of Rochester Medical Center)

  • Jemma V. Rowlands

    (New York State Department of Health)

  • Shannon A. Seopaul

    (Johns Hopkins Bloomberg School of Public Health)

  • Ann R. Thomas

    (Oregon Health Authority)

  • Htet Htet N. Wrigley

    (Connecticut Department of Public Health)

  • Lesley McGee

    (Centers for Disease Control and Prevention)

  • Sundaram Ajay Vishwanathan

    (Centers for Disease Control and Prevention)

  • Fahmina Akhter

    (Centers for Disease Control and Prevention)

  • Bailey Alston

    (Seneca Federal Health)

  • Lily Tao Jia

    (Centers for Disease Control and Prevention)

  • Yikun Li

    (Inc)

  • Palak Y. Patel

    (Centers for Disease Control and Prevention)

  • Joy Rivers

    (Centers for Disease Control and Prevention)

  • Jessica E. Southwell

    (Inc)

  • Theresa Tran

    (Centers for Disease Control and Prevention)

  • Panagiotis Maniatis

    (Centers for Disease Control and Prevention)

  • Stephanie J. Schrag

    (Centers for Disease Control and Prevention)

Abstract

Maternal vaccines to prevent infant Group B Streptococcus (GBS) disease have progressed through phase II development and may be licensed based on immunologic endpoints, which have yet to be approved by regulatory authorities. Here we present a multistate case control study to characterize the relationship between serotype-specific anti-capsular polysaccharide (CPS) immunoglobulin G concentrations near birth and infant GBS disease risk reduction. Antibody concentration distributions are significantly lower for cases (n = 643) than controls (n = 2801) and serologic thresholds varied by serotype and age at onset, with 80% serotype-specific protective thresholds ranging from 0.52 to 2.49 mcg/mL for early-onset disease (EOD;

Suggested Citation

  • Julia C. Rhodes & Rebecca Kahn & Shanna Bolcen & Nong Shang & Yunmi Chung & Monica M. Farley & Amber N. Britton & Ashley E. Moore & Stepy Thomas & Joelle Nadle & Laura B. Amsden & Jacek Skarbinski & K, 2025. "A US case-control study to estimate infant group B streptococcal disease serological thresholds of risk-reduction," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64324-y
    DOI: 10.1038/s41467-025-64324-y
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