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CurT/CURT1 proteins are involved in cell and chloroplast division coordination of cyanobacteria and green algae

Author

Listed:
  • Marcel Dann

    (Technical University of Darmstadt
    National Institute for Basic Biology
    Ludwig-Maximilians University Munich)

  • Eunchul Kim

    (National Institute for Basic Biology
    Nihon University)

  • Konomi Fujimura-Kamada

    (National Institute for Basic Biology)

  • Vjosa Berisha

    (Technical University of Darmstadt)

  • Mami Nomura

    (Yamagata University)

  • Anne-Christin Pohland

    (Technical University of Darmstadt)

  • Mai Watanabe

    (Technical University of Darmstadt)

  • Matthias Ostermeier

    (Ludwig-Maximilians University Munich)

  • Frederik Sommer

    (RPTU Kaiserslautern-Landau)

  • Michael Schroda

    (RPTU Kaiserslautern-Landau)

  • Shin-ya Miyagishima

    (National Institute of Genetics Japan)

  • Jun Minagawa

    (National Institute for Basic Biology)

Abstract

Plant proteins of the CURVATURE THYLAKOID 1 (CURT1) family and their prokaryotic CurT homologues are key determinants of the three-dimensional structure of the thylakoid membrane systems in chloroplasts and cyanobacteria. As the evolutionary origin of the CURT1/CurT family appears to coincide with the evolution of thylakoids themselves, shaping the thylakoid system has widely been regarded as their primary role. In this study we present strong evidence that CurT, beyond regulation of thylakoid architecture, is involved in cell division and thylakoid fission/partitioning in both Synechocystis sp. PCC 6803 and Synechococcus elongatus PCC 7942, likely through physical interaction with the key cell division protein FtsZ. Similarly, triple mutants of Chlamydomonas reinhardtii CURT1A, B, and C display an asymmetric chloroplast division phenotype, thus suggesting an evolutionary conserved functionality of CurT/CURT1 in cell/chloroplast division in single-celled oxygenic photosynthesizers.

Suggested Citation

  • Marcel Dann & Eunchul Kim & Konomi Fujimura-Kamada & Vjosa Berisha & Mami Nomura & Anne-Christin Pohland & Mai Watanabe & Matthias Ostermeier & Frederik Sommer & Michael Schroda & Shin-ya Miyagishima , 2025. "CurT/CURT1 proteins are involved in cell and chloroplast division coordination of cyanobacteria and green algae," Nature Communications, Nature, vol. 16(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64163-x
    DOI: 10.1038/s41467-025-64163-x
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    1. Nika Pende & Adrià Sogues & Daniela Megrian & Anna Sartori-Rupp & Patrick England & Hayk Palabikyan & Simon K.-M. R. Rittmann & Martín Graña & Anne Marie Wehenkel & Pedro M. Alzari & Simonetta Gribald, 2021. "SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Kevin L. Yang & Fengchao Yu & Guo Ci Teo & Kai Li & Vadim Demichev & Markus Ralser & Alexey I. Nesvizhskii, 2023. "MSBooster: improving peptide identification rates using deep learning-based features," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Phillip Nußbaum & Maren Gerstner & Marie Dingethal & Celine Erb & Sonja-Verena Albers, 2021. "The archaeal protein SepF is essential for cell division in Haloferax volcanii," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
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