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Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans

Author

Listed:
  • Emmanouil Kyriakakis

    (University of Basel)

  • Chiara Medde

    (University of Basel)

  • Danilo Ritz

    (University of Basel)

  • Geoffrey Fucile

    (University of Basel
    University of Basel)

  • Alexander Schmidt

    (University of Basel)

  • Anne Spang

    (University of Basel)

Abstract

Life expectancy has been increasing over the last decades, which is not matched by an increase in healthspan. Besides genetic composition, environmental and nutritional factors influence both health- and lifespan. Diet is thought to be a major factor for healthy ageing. Here, we show that dietary RNA species improve proteostasis in C. elegans. Inherent bacterial-derived double stranded RNA reduces protein aggregation in a C. elegans muscle proteostasis model. This beneficial effect depends on low levels of systemic selective autophagy, the RNAi machinery in the germline, even when the RNA is delivered through ingestion in the intestine and the integrity of muscle cells. Our data suggest a requirement of inter-organ communication between the intestine, the germline and muscles. Our results demonstrate that bacterial-derived RNAs elicit a systemic response in C. elegans, which protects the animal from protein aggregation during ageing, which might extend healthspan.

Suggested Citation

  • Emmanouil Kyriakakis & Chiara Medde & Danilo Ritz & Geoffrey Fucile & Alexander Schmidt & Anne Spang, 2025. "Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63987-x
    DOI: 10.1038/s41467-025-63987-x
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    References listed on IDEAS

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    1. Huijie Liu & Xueren Wang & Horng-Dar Wang & JinJing Wu & Jing Ren & Lingfeng Meng & Qingfa Wu & Hansheng Dong & Jing Wu & Tzu-Yu Kao & Qian Ge & Zheng-xing Wu & Chiou-Hwa Yuh & Ge Shan, 2012. "Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans," Nature Communications, Nature, vol. 3(1), pages 1-11, January.
    2. Arles Urrutia & Víctor A García-Angulo & Andrés Fuentes & Mauricio Caneo & Marcela Legüe & Sebastián Urquiza & Scarlett E Delgado & Juan Ugalde & Paula Burdisso & Andrea Calixto, 2020. "Bacterially produced metabolites protect C . elegans neurons from degeneration," PLOS Biology, Public Library of Science, vol. 18(3), pages 1-31, March.
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