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Chiral dependence of multifunctional supramolecular materials in crop protection

Author

Listed:
  • Min Liu

    (Center for Research and Development of Fine Chemicals of Guizhou University)

  • Kongjun Liu

    (Center for Research and Development of Fine Chemicals of Guizhou University
    Zunyi Medical University)

  • Jinghan Yang

    (Center for Research and Development of Fine Chemicals of Guizhou University)

  • Juan Liu

    (Center for Research and Development of Fine Chemicals of Guizhou University)

  • Peiyi Wang

    (Center for Research and Development of Fine Chemicals of Guizhou University)

Abstract

Chiral pesticides have captivated considerable interest in agriculture, yet the integration of chirality into multifunctional supramolecular materials within this sector remains uncharted. Here, we show the fabrication of chiral AIM-12S/R@β-CD by encapsulating AIM-12S/R within β-cyclodextrin (β-CD), designed to enhance foliar adhesion and biofilm disruption for effective management of rice bacterial blight. Upon assembly in aqueous media, the chiral disparities in foliar affinity and biofilm disruption, initially present in AIM-12S/R, are amplified, as evidenced by a 67° lower contact angle for AIM-12R@β-CD relative to its S-enantiomer, and an 8.5-fold increase in biofilm eradication at 12.5 μg·mL⁻¹. Despite comparable in vitro potency, which often obscures chiral influences on other traits, enantioselective interactions between the enantiomers with leaf surfaces and biofilms dictate the divergence in in planta efficacy. This work provides a demonstration of chiral discrimination in supramolecular agrochemicals, presenting valuable insights into the further deployment of chiral supermolecules in agriculture.

Suggested Citation

  • Min Liu & Kongjun Liu & Jinghan Yang & Juan Liu & Peiyi Wang, 2025. "Chiral dependence of multifunctional supramolecular materials in crop protection," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63677-8
    DOI: 10.1038/s41467-025-63677-8
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    References listed on IDEAS

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    1. B. P. Conlon & E. S. Nakayasu & L. E. Fleck & M. D. LaFleur & V. M. Isabella & K. Coleman & S. N. Leonard & R. D. Smith & J. N. Adkins & K. Lewis, 2013. "Activated ClpP kills persisters and eradicates a chronic biofilm infection," Nature, Nature, vol. 503(7476), pages 365-370, November.
    2. Anaïs Gauthier & Sean Symon & Christophe Clanet & David Quéré, 2015. "Water impacting on superhydrophobic macrotextures," Nature Communications, Nature, vol. 6(1), pages 1-6, November.
    3. Jintao Liu & Arthur Prindle & Jacqueline Humphries & Marçal Gabalda-Sagarra & Munehiro Asally & Dong-yeon D. Lee & San Ly & Jordi Garcia-Ojalvo & Gürol M. Süel, 2015. "Metabolic co-dependence gives rise to collective oscillations within biofilms," Nature, Nature, vol. 523(7562), pages 550-554, July.
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