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Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infection

Author

Listed:
  • Lachlan L. Walker

    (The University of Queensland
    The University of Queensland)

  • Minh-Duy Phan

    (The University of Queensland
    The University of Queensland)

  • Budi Permana

    (The University of Queensland
    The University of Queensland)

  • Zheng Jie Lian

    (The University of Queensland
    The University of Queensland)

  • Nguyen Thi Khanh Nhu

    (The University of Queensland
    The University of Queensland)

  • Thom Cuddihy

    (The University of Queensland
    The University of Queensland)

  • Kate M. Peters

    (The University of Queensland
    The University of Queensland)

  • Kay A. Ramsay

    (The University of Queensland)

  • Chelsea Stewart

    (The University of Queensland
    The University of Queensland)

  • Niels Pfennigwerth

    (Ruhr-University Bochum)

  • Timothy J. Kidd

    (Queensland Health)

  • Patrick N. A. Harris

    (The University of Queensland
    Queensland Health)

  • David L. Paterson

    (National University of Singapore)

  • Matthew J. Sweet

    (The University of Queensland
    The University of Queensland)

  • Brian M. Forde

    (The University of Queensland
    The University of Queensland
    The University of Queensland)

  • Mark A. Schembri

    (The University of Queensland
    The University of Queensland
    The University of Queensland)

Abstract

Carbapenem-resistant Enterobacterales pose a critical global health threat, exemplified by increasing resistance of uropathogenic E. coli (UPEC) that cause urinary tract infections (UTIs). Here, we investigate the publicly available EnteroBase dataset and identify a signal of increasing UTI caused by phylogroup A E. coli sequence type 167 (ST167). Phylogenetic analysis of ST167 based on whole genome sequence data reveal three major clades (A, B, C), with clade C further resolving into several subclades, notably subclade C2 that possessed high carriage rates of carbapenem and cephalosporin resistance genes. Hierarchical clustering of core genome multi-locus sequence typing reveals ~77% of subclade C2 strains contain

Suggested Citation

  • Lachlan L. Walker & Minh-Duy Phan & Budi Permana & Zheng Jie Lian & Nguyen Thi Khanh Nhu & Thom Cuddihy & Kate M. Peters & Kay A. Ramsay & Chelsea Stewart & Niels Pfennigwerth & Timothy J. Kidd & Patr, 2025. "Emergence of a carbapenem-resistant atypical uropathogenic Escherichia coli clone as an increasing cause of urinary tract infection," Nature Communications, Nature, vol. 16(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63477-0
    DOI: 10.1038/s41467-025-63477-0
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