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Organic-inorganic covalent selenium reversing ischemic reperfusion injury

Author

Listed:
  • Zushuang Xiong

    (Jinan University
    Jinan University
    Jinan University)

  • Guanning Huang

    (Jinan University
    Jinan University)

  • Jia-Run Huang

    (Jinan University)

  • Ying Liu

    (Jinan University)

  • Lizhen He

    (Jinan University)

  • Tianfeng Chen

    (Jinan University
    Jinan University
    Jinan University)

Abstract

Clear elucidation of the connection between chemical structure and biological action mechanisms is the key issue preventing the successful development of nanomedicines. Herein, employing essential trace element selenium (Se) as an example, we fabricate organic-inorganic covalent Se hybrid by anchoring Se atom to polyethylene glycol chain during carbonization to form organic Se-C and inorganic Se-Se bonds in one system to integrate the advantages of both species. The weak covalent Se-Se bond breaks down in response to redox stimuli, thus releases organic Se with stronger electron transfer ability to scavenge free radicals, and forms highly active inorganic Se, which further releases free Se atom to trigger selenoprotein synthesis and activation, ultimately reverses reperfusion injury in male-mice ischemic stroke, and improves neurological restoration. This work provides a unique Se atom reprogramming strategy to design highly bioactive hybrid Se species with clear chemical nature and action mechanisms.

Suggested Citation

  • Zushuang Xiong & Guanning Huang & Jia-Run Huang & Ying Liu & Lizhen He & Tianfeng Chen, 2025. "Organic-inorganic covalent selenium reversing ischemic reperfusion injury," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62986-2
    DOI: 10.1038/s41467-025-62986-2
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    References listed on IDEAS

    as
    1. Morteza Mahmoudi, 2021. "The need for robust characterization of nanomaterials for nanomedicine applications," Nature Communications, Nature, vol. 12(1), pages 1-5, December.
    2. Minghao Wang & Chen Nie & Junbang Liu & Si Wu, 2023. "Organic‒inorganic semi-interpenetrating networks with orthogonal light- and magnetic-responsiveness for smart photonic gels," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Chase M. Kayrouz & Jonathan Huang & Nicole Hauser & Mohammad R. Seyedsayamdost, 2022. "Biosynthesis of selenium-containing small molecules in diverse microorganisms," Nature, Nature, vol. 610(7930), pages 199-204, October.
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