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Direct chiroptical correlation of dissymmetric crystal morphologies

Author

Listed:
  • Qiang Wen

    (Weizmann Institute of Science)

  • Melissa Tan

    (New York University)

  • Ofir Eisenberg

    (Weizmann Institute of Science)

  • Hadar Nasi

    (Weizmann Institute of Science)

  • Vlad Brumfeld

    (Weizmann Institute of Science)

  • Akash Tiwari

    (New York University)

  • Hai-Mu Ye

    (New York University)

  • Bart Kahr

    (New York University)

  • Linda J. W. Shimon

    (Weizmann Institute of Science)

  • Michal Lahav

    (Weizmann Institute of Science)

  • Milko E. Boom

    (Weizmann Institute of Science)

Abstract

The expression of molecular dissymmetry in crystal form has been studied since Pasteur correlated macroscopic and microscopic chirality by measuring the optical activity of solutions of enantiomorphous tartrate salt crystals. Here, we show a direct correlation between enantiomorphous metal-organic framework (MOF) crystals and the chirality of the molecular structure. The geometry of the habits is correlated with single-crystal optical activity along the accessible low-symmetry directions. Weak X-ray scattering from small crystals was consistent with a hexagonal, enantiomorphous space group. However, the heterochirality of the mirror image forms could not be established with X-rays, necessitating a different approach. The optical circular birefringence of the enantiomorphs as evidenced by chiroptical imaging with a complete polarimetric microscope, was used to correlate optical and morphological chirality.

Suggested Citation

  • Qiang Wen & Melissa Tan & Ofir Eisenberg & Hadar Nasi & Vlad Brumfeld & Akash Tiwari & Hai-Mu Ye & Bart Kahr & Linda J. W. Shimon & Michal Lahav & Milko E. Boom, 2025. "Direct chiroptical correlation of dissymmetric crystal morphologies," Nature Communications, Nature, vol. 16(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62889-2
    DOI: 10.1038/s41467-025-62889-2
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    References listed on IDEAS

    as
    1. Maria Chiara di Gregorio & Linda J. W. Shimon & Vlad Brumfeld & Lothar Houben & Michal Lahav & Milko E. van der Boom, 2020. "Emergence of chirality and structural complexity in single crystals at the molecular and morphological levels," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    2. C.A. Orme & A. Noy & A. Wierzbicki & M. T. McBride & M. Grantham & H.H. Teng & P.M. Dove & J.J. DeYoreo, 2001. "Formation of chiral morphologies through selective binding of amino acids to calcite surface steps," Nature, Nature, vol. 411(6839), pages 775-779, June.
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