Author
Listed:
- Tao Wu
(Shenyang University of Technology
Northeastern University)
- Tenghui Li
(The First Hospital of China Medical University
China Medical University)
- Chengzhi Zhang
(The First Hospital of China Medical University
China Medical University)
- Yu Tian
(Shenyang University of Technology)
- Hao Li
(Shenyang University of Technology)
- Yuxin He
(The First Hospital of China Medical University)
- Xu Yan
(China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases)
- Tianxing Gong
(Shenyang University of Technology)
- Junhua Zhao
(The First Hospital of China Medical University
China Medical University)
- Zhenning Wang
(The First Hospital of China Medical University
China Medical University)
Abstract
Preserving anal function in advanced-stage colorectal cancer (CRC) treatment remains a significant challenge. Here we introduce a hollow-tube-like hydrospongel (HTHSG) as an advanced neoadjuvant therapy. Constructed from cellulose nanofibers crosslinked with Fe3O4@PDA (polydopamine) nanoparticles, the HTHSG combines quick swelling (~10 seconds) with high fracture strength (>250 kPa) for enhanced mechanical stability. The hydrospongel enables precise, localized delivery of the chemotherapeutic agent 5-FU directly to the tumor site. Beyond conventional chemotherapy, HTHSG employs electromagnetic induction to achieve targeted thermal ablation and chemodynamic therapy, minimizing collateral damage to healthy tissues. Comparative studies in orthotopic, cell-derived, and patient-derived xenograft models demonstrate the superior tumor-reduction efficacy of HTHSG over traditional neoadjuvant therapies. Feasibility studies in a beagle model and human-sized dummy model further validate the HTHSG’s potential for clinical application, showing preserved anal function and biocompatibility. These findings establish HTHSG as a promising pre-surgical treatment option for advanced-stage CRC, offering improved therapeutic outcomes and quality of life for patients.
Suggested Citation
Tao Wu & Tenghui Li & Chengzhi Zhang & Yu Tian & Hao Li & Yuxin He & Xu Yan & Tianxing Gong & Junhua Zhao & Zhenning Wang, 2025.
"A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer,"
Nature Communications, Nature, vol. 16(1), pages 1-19, December.
Handle:
RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62880-x
DOI: 10.1038/s41467-025-62880-x
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62880-x. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.