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Dynamic pathways in energy landscapes guiding supramolecular Janus dendrimer self-assemblies between lamellar and cubic architectures

Author

Listed:
  • Jiabin Luan

    (Radboud University)

  • Danni Wang

    (Radboud University)

  • Niels P. Kok

    (Radboud University)

  • Neshat Moslehi

    (Eindhoven University of Technology)

  • Ilja K. Voets

    (Eindhoven University of Technology)

  • Daniela A. Wilson

    (Radboud University)

Abstract

Elaborate kinetic control enables supramolecular self-assemblies to deviate from equilibrium, depicting profound energy landscapes with remarkable structural and functional diversity. Despite this potential, achieving an energy landscape that encompasses lamellar and inverse cubic structures remains a significant challenge, contrasting with the sophisticated structural transformations naturally orchestrated by cellular systems. Here, we present a dynamic and minimalistic Janus dendrimer self-assembly system capable of reversibly transitioning between lamellar vesicles and inverse cubic structures. By exploiting temperature-triggered non-covalent interactions, including OEG interdigitation and hydrogen bonding, conformational flexibility, and molecular packing, we reveal a rich energy landscape featuring diverse assembly pathways spanning lamellar vesicles and inverse cubosomes. Our study not only enriches the structural versatility of Janus dendrimer assemblies but also provides a foundation for advancing supramolecular systems toward applications in biomedicine, catalysis, and beyond.

Suggested Citation

  • Jiabin Luan & Danni Wang & Niels P. Kok & Neshat Moslehi & Ilja K. Voets & Daniela A. Wilson, 2025. "Dynamic pathways in energy landscapes guiding supramolecular Janus dendrimer self-assemblies between lamellar and cubic architectures," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62866-9
    DOI: 10.1038/s41467-025-62866-9
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    References listed on IDEAS

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    1. Davide Demurtas & Paul Guichard & Isabelle Martiel & Raffaele Mezzenga & Cécile Hébert & Laurent Sagalowicz, 2015. "Direct visualization of dispersed lipid bicontinuous cubic phases by cryo-electron tomography," Nature Communications, Nature, vol. 6(1), pages 1-8, December.
    2. Roy Pattipeiluhu & Ye Zeng & Marco M.R.M. Hendrix & Ilja K. Voets & Alexander Kros & Thomas H. Sharp, 2024. "Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
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