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Dynamically urethra-adapted and obligations-oriented trilayer hydrogels integrate scarless urethral repair

Author

Listed:
  • Ming Yang

    (Shanghai Jiaotong University
    University of Electronic Science and Technology of China)

  • Maocheng Zuo

    (University of Electronic Science and Technology of China)

  • Ranxing Yang

    (Shanghai Jiaotong University)

  • Kaile Zhang

    (Shanghai Jiaotong University)

  • Ruonan Jia

    (University of Electronic Science and Technology of China)

  • Binxu Yin

    (University of Electronic Science and Technology of China)

  • Ying Wang

    (Shanghai Jiaotong University)

  • Meng Liu

    (Shanghai Jiaotong University)

  • Wenzhuo Fang

    (Shanghai Jiaotong University)

  • Huaijuan Guo

    (University of Electronic Science and Technology of China)

  • Yangwang Jin

    (Shanghai Jiaotong University)

  • Qiang Fu

    (Shanghai Jiaotong University)

  • Kun Zhang

    (University of Electronic Science and Technology of China)

Abstract

In urethral damage/stricture prevention, open and harsh urethral microenvironments and isotropic compression and swelling properties of exogenous implants render urethral repair intractable. Here a dynamically urethra-adapted and obligations-oriented trilayer hydrogel was engineered to integrate scarless urethral repair. Therein, the diethylacrylamide-hydroxyethylacrylamide (HEAm) (D-H) hydrogel layer featuring high anti-fouling performance prevent adhesions of bacterial and blood cells, and its poor swelling avoids urethra occlusion. The upper swellable and verteporfin (VP)-loaded N,N’-methylenebisacrylamide-poly (N-isopropylacrylamide) (BP) layer encourages urethra regeneration through expediting cell migration and proliferation. The rigid and water-resistant Zein middle layer opposes urine voiding-arised BP shedding, urethral diastole/contraction, inward BP swelling-arised urethra occlusion and urine permeation. Importantly, systematic proteomic and genomic analysis reveals that such hydrogel scaffolds expedite epithelial & vascular regenerations, attenuate tight cell junction, oppose inflammation microenvironment and regulate extracellular matrix secretion and metabolism to realize integrated urethral repair. The microenvironment-adaptable design concepts provide reliable rationales to engineer urethral regeneration scaffolds.

Suggested Citation

  • Ming Yang & Maocheng Zuo & Ranxing Yang & Kaile Zhang & Ruonan Jia & Binxu Yin & Ying Wang & Meng Liu & Wenzhuo Fang & Huaijuan Guo & Yangwang Jin & Qiang Fu & Kun Zhang, 2025. "Dynamically urethra-adapted and obligations-oriented trilayer hydrogels integrate scarless urethral repair," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62851-2
    DOI: 10.1038/s41467-025-62851-2
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    References listed on IDEAS

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