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Worldwide genetic diversity of Plasmodium vivax Pv47 is consistent with natural selection by anopheline mosquitoes

Author

Listed:
  • Alvaro Molina-Cruz

    (National Institutes of Health)

  • Lilia Gonzalez-Ceron

    (Instituto Nacional de Salud Pública)

  • Ankit Dwivedi

    (University of Maryland School of Medicine)

  • Tran Zen B. Torres

    (National Institutes of Health)

  • Nadia Raytselis

    (National Institutes of Health)

  • Micah Young

    (National Institutes of Health)

  • Nitin Kamath

    (National Institutes of Health)

  • Colton McNinch

    (National Institutes of Health)

  • Xinzhuan Su

    (National Institutes of Health)

  • Anthony Ford

    (University of North Carolina at Charlotte
    University of North Carolina at Charlotte
    University of North Carolina at Charlotte)

  • Marcelo U. Ferreira

    (University of São Paulo
    NOVA University of Lisbon)

  • Myriam Arévalo-Herrera

    (Malaria Vaccine and Drug Development Center)

  • Sócrates Herrera

    (Malaria Vaccine and Drug Development Center)

  • Eugenia Lo

    (University of North Carolina at Charlotte)

  • Joana C. Silva

    (University of Maryland School of Medicine)

  • Carolina Barillas-Mury

    (National Institutes of Health)

Abstract

Pv47 is the Plasmodium vivax ortholog of Pfs47, a protein that allows the Plasmodium falciparum malaria parasite to evade mosquito immunity and adapt to diverse vectors. We analyzed global genetic diversity of Pv47 and compared it with Pfs47, finding that most common Pv47 polymorphisms are non-synonymous and cluster in regions similar to those in Pfs47. Pv47 domain 2 presents an excess of non-synonymous substitutions, suggesting positive selection. The greatest haplotype diversity is found in Pv47 from East/Southeast Asia and Oceania. Like Pfs47, Pv47 also exhibits a marked geographic population structure worldwide. Notably, a Pv47 polymorphism (K27E) is associated to differences in infectivity to Anopheles (Nyssorhynchus) albimanus and Anopheles pseudopunctipennis, two phylogenetically distant vectors in Mexico. The striking similarities in genetic diversity, population structure, and signatures of natural selection between Pv47 and Pfs47 suggest that adaptation to different Anopheline mosquito species drives Pv47 diversity by selecting compatible Pv47 haplotypes.

Suggested Citation

  • Alvaro Molina-Cruz & Lilia Gonzalez-Ceron & Ankit Dwivedi & Tran Zen B. Torres & Nadia Raytselis & Micah Young & Nitin Kamath & Colton McNinch & Xinzhuan Su & Anthony Ford & Marcelo U. Ferreira & Myri, 2025. "Worldwide genetic diversity of Plasmodium vivax Pv47 is consistent with natural selection by anopheline mosquitoes," Nature Communications, Nature, vol. 16(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62680-3
    DOI: 10.1038/s41467-025-62680-3
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