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Skeletal editing of pyridines to aryldialdehydes

Author

Listed:
  • Meixin Yan

    (Sichuan University)

  • Yonglin Shi

    (Sichuan University)

  • Cong Lv

    (Sichuan University)

  • Shunyao Huang

    (Sichuan University)

  • Shun Li

    (Sichuan University
    Leshan Normal University)

  • Dexi Yang

    (Sichuan University)

  • Jiangui Zhao

    (Sichuan University)

  • Zhishan Su

    (Sichuan University)

  • Weidong Jiang

    (Sichuan University of Science and Engineering)

  • Weichao Xue

    (Sichuan University)

  • Jiaqi Xu

    (Sichuan University)

  • Xueli Zheng

    (Sichuan University)

  • Ruixiang Li

    (Sichuan University)

  • Hua Chen

    (Sichuan University)

  • Haiyan Fu

    (Sichuan University)

Abstract

Electron-deficient nitrogen-containing aromatic heterocycles, particularly pyridine derivatives, can be converted into all-carbon aromatic frameworks via the ANRORC (Addition of Nucleophile, Ring-Opening, and Ring-Closing) skeletal editing process, providing a convenient tool for molecular diversification. However, reported methods are mainly limited to nucleophilic modification of ring-opening species. Herein, we report a distinct electrophilic modification method, smoothly converting pyridines into arene-1,3-dialdehydes or naphthalene-1,3-dialdehydes.

Suggested Citation

  • Meixin Yan & Yonglin Shi & Cong Lv & Shunyao Huang & Shun Li & Dexi Yang & Jiangui Zhao & Zhishan Su & Weidong Jiang & Weichao Xue & Jiaqi Xu & Xueli Zheng & Ruixiang Li & Hua Chen & Haiyan Fu, 2025. "Skeletal editing of pyridines to aryldialdehydes," Nature Communications, Nature, vol. 16(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62627-8
    DOI: 10.1038/s41467-025-62627-8
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