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Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation

Author

Listed:
  • Shriya Srinivasan

    (Massachusetts Institute of Technology
    Harvard Medical School
    Massachusetts Institute of Technology
    Harvard University)

  • Marc-Joseph Antonini

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Amro Alshareef

    (Massachusetts Institute of Technology
    Harvard Medical School
    Massachusetts Institute of Technology)

  • Atharva Sahasrabudhe

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Josh Jenkins

    (Massachusetts Institute of Technology)

  • Keiko Ishida

    (Massachusetts Institute of Technology
    Harvard Medical School
    Massachusetts Institute of Technology)

  • Johannes Kuosmanen

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Alison Hayward

    (Massachusetts Institute of Technology
    Harvard Medical School
    Massachusetts Institute of Technology)

  • Seokkee Min

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Robert Langer

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Polina Anikeeva

    (Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Massachusetts Institute of Technology
    Massachusetts Institute of Technology)

  • Giovanni Traverso

    (Massachusetts Institute of Technology
    Harvard Medical School)

Abstract

Gastrointestinal (GI) dysmotility and associated conditions affect over 20% of population, yet pharmacological, behavioural, and surgical interventions offer limited therapeutic efficacy. Targeted electrical stimulation addressing underlying neuromuscular pathology stands to transform our ability to treat dysmotility. Here, we developed a closed-loop GI neuroprosthesis which activates or relaxes GI tract musculature through electrochemical stimulation in response to sensed food stimuli. We additionally describe a tool supporting minimally invasive endoscopically guided implantation that can penetrate the mucosa, accurately localize the submucosa, and safely deploy this device to directly interface with the enteric nervous system. The neuroprosthesis enables generation of coordinated peristaltic waves, significantly increasing the motility rate in a swine model of oesophageal and stomach dysmotility (p

Suggested Citation

  • Shriya Srinivasan & Marc-Joseph Antonini & Amro Alshareef & Atharva Sahasrabudhe & Josh Jenkins & Keiko Ishida & Johannes Kuosmanen & Alison Hayward & Seokkee Min & Robert Langer & Polina Anikeeva & G, 2025. "Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62413-6
    DOI: 10.1038/s41467-025-62413-6
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    References listed on IDEAS

    as
    1. Shriya S. Srinivasan & Benjamin E. Maimon & Maurizio Diaz & Hyungeun Song & Hugh M. Herr, 2018. "Closed-loop functional optogenetic stimulation," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    2. Javier Aguilera-Lizarraga & Morgane V. Florens & Maria Francesca Viola & Piyush Jain & Lisse Decraecker & Iris Appeltans & Maria Cuende-Estevez & Naomi Fabre & Kim Van Beek & Eluisa Perna & Dafne Bale, 2021. "Local immune response to food antigens drives meal-induced abdominal pain," Nature, Nature, vol. 590(7844), pages 151-156, February.
    Full references (including those not matched with items on IDEAS)

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