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P-stereogenic centre via Pd/Cu-bimetallic catalytic selective phosphinylation of allenylic acetates

Author

Listed:
  • Gen Li

    (Anhui Agricultural University)

  • Shichao Hong

    (Fudan University)

  • Xuechen Li

    (Anhui Agricultural University)

  • Wenhao Zhao

    (Anhui Agricultural University)

  • Chaobo Ye

    (Anhui Agricultural University)

  • Yi Yu

    (Anhui Agricultural University)

  • Huajie Jiang

    (Anhui Agricultural University)

  • Jie Yu

    (Anhui Agricultural University)

  • Xue Zhang

    (University of Chinese Academy of Sciences)

  • Shengming Ma

    (Fudan University
    University of Chinese Academy of Sciences)

  • Qiankun Li

    (Anhui Agricultural University)

Abstract

P-stereogenic organophosphorus compounds are a class of highly important compounds due to their potentials in asymmetric catalysis both as ligands or catalysts and medicinal chemistry. Herein, we report an efficient protocol under bimetallic catalysis of Pd/Cu for highly regio-, E- and enantioselective phosphinylation of allenylic acetates with racemic secondary phosphine oxides forming a wide range of versatile P-stereogenic 1,3-dienyl phosphine oxides with 86–95% ee. The regioselectivity is unique as compared to the traditional catalytic enantioselective allenylations.

Suggested Citation

  • Gen Li & Shichao Hong & Xuechen Li & Wenhao Zhao & Chaobo Ye & Yi Yu & Huajie Jiang & Jie Yu & Xue Zhang & Shengming Ma & Qiankun Li, 2025. "P-stereogenic centre via Pd/Cu-bimetallic catalytic selective phosphinylation of allenylic acetates," Nature Communications, Nature, vol. 16(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-62204-z
    DOI: 10.1038/s41467-025-62204-z
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