IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-61889-6.html
   My bibliography  Save this article

Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity

Author

Listed:
  • Sara D. Lolansen

    (University of Copenhagen
    University Hospital of Copenhagen - Rigshospitalet)

  • Eszter O. Révész

    (University of Copenhagen)

  • Søren N. Andreassen

    (University of Copenhagen)

  • Marleen Trapp

    (German Cancer Research Center (DKFZ))

  • Chiara Salio

    (University of Turin)

  • Marco Sassoé-Pognetto

    (University of Turin)

  • Jens Velde Andersen

    (University of Copenhagen)

  • Emil W. Westi

    (University of Copenhagen)

  • Trine L. Toft-Bertelsen

    (University of Copenhagen)

  • Jonathan H. Wardman

    (University of Copenhagen)

  • Anne-Kristine Meinild Lundby

    (University of Copenhagen)

  • Flemming Dela

    (University of Copenhagen
    Riga Stradins University)

  • Annarita Patrizi

    (German Cancer Research Center (DKFZ)
    Heidelberg University)

  • Blanca I. Aldana

    (University of Copenhagen)

  • Nanna MacAulay

    (University of Copenhagen)

Abstract

Our brain is bathed in cerebrospinal fluid (CSF) that is produced by the choroid plexus. CSF serves as a dispersion route for hormones and nutrients, and a conduit for waste clearance. Age-dependent reduction in the CSF secretion rate could influence cerebral waste clearance and thereby promote cognitive deficits in the elderly. Here, we resolve age-dependent modulation of CSF dynamics and choroid plexus function by complementary in vivo determinations of intracranial pressure (ICP) and CSF secretion/absorption rates, combined with transcriptomic, morphological, and metabolic analysis of choroid plexus in aging male rats. ICP and CSF secretion rate and absorption capacity remain stable with age, and the choroid plexus retains its morphology, structural integrity, gene expression, and high metabolic rate across the tested ages. This work supports the significance of choroid plexus function for brain aging and promotes this tissue as a future target for neurodegenerative diseases associated with impaired waste clearance and cognitive decline.

Suggested Citation

  • Sara D. Lolansen & Eszter O. Révész & Søren N. Andreassen & Marleen Trapp & Chiara Salio & Marco Sassoé-Pognetto & Jens Velde Andersen & Emil W. Westi & Trine L. Toft-Bertelsen & Jonathan H. Wardman &, 2025. "Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61889-6
    DOI: 10.1038/s41467-025-61889-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-61889-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-61889-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61889-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.