IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-61842-7.html
   My bibliography  Save this article

CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis

Author

Listed:
  • Hao Sun

    (Sun Yat-sen University)

  • Xiaobin Lin

    (Sun Yat-sen University)

  • Fangzhou Liu

    (Sun Yat-sen University)

  • Yingbin Zhang

    (Sun Yat-sen University)

  • Jianda Ma

    (Sun Yat-sen University)

  • Zhencheng Huang

    (Sun Yat-sen University)

  • Junming Huang

    (Sun Yat-sen University)

  • Lutian Yao

    (China Medical University)

  • Mengyuan Zhang

    (Sun Yat-sen University)

  • Meiyi Chen

    (Sun Yat-sen University)

  • Jie Xu

    (Sun Yat-sen University)

  • Yulong Wei

    (Huazhong University of Science and Technology)

  • Lie Dai

    (Sun Yat-sen University)

  • Ruofan Ma

    (Sun Yat-sen University)

Abstract

Previous evidence suggest bone and cartilage damage is the main pathogenesis of rheumatoid arthritis joint destruction. However, the role of meniscus usually has not been thoroughly explored. Here, we identify CD142+ synovial fibroblasts as a subset located at sublining layer in normal and osteoarthritis synovium, which is increased and distributed at lining layer in rheumatoid arthritis synovium. Injection of CD142+ fibroblasts into DBA/1 male mice’s knee destructs meniscus but has slight effect on cartilage. ABCC4 is highly expressed in CD142+ fibroblasts, whose blockage by MK571 attenuates CD142+ fibroblasts-induced meniscus destruction through cAMP/PKA signaling. Long-term follow-up of rheumatoid arthritis cohort indicates that enriched CD142+ fibroblasts at lining layer are a risk factor for severe knee joint destruction and eventually undergo total knee arthroplasty. Our results demonstrate CD142+ fibroblasts as an indicator to assess prognosis and a therapeutic target to inhibit meniscal destruction, thereby alleviating rheumatoid arthritis knee joint damage.

Suggested Citation

  • Hao Sun & Xiaobin Lin & Fangzhou Liu & Yingbin Zhang & Jianda Ma & Zhencheng Huang & Junming Huang & Lutian Yao & Mengyuan Zhang & Meiyi Chen & Jie Xu & Yulong Wei & Lie Dai & Ruofan Ma, 2025. "CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61842-7
    DOI: 10.1038/s41467-025-61842-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-61842-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-61842-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61842-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.