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Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila

Author

Listed:
  • Eloïse Tredern

    (Institut des neurosciences Paris-Saclay)

  • Dylan Manceau

    (Institut des neurosciences Paris-Saclay)

  • Alexandre Blanc

    (Decision and Bayesian Computation
    INRIA)

  • Abhijit Parameswaran

    (Institut des neurosciences Paris-Saclay)

  • Panagiotis Sakagiannis

    (University of Cologne)

  • Chloe Barre

    (Decision and Bayesian Computation
    INRIA)

  • Victoria Sus

    (Institut des neurosciences Paris-Saclay)

  • Francesca Viscido

    (Institut des neurosciences Paris-Saclay)

  • Perla Akiki

    (Institut des neurosciences Paris-Saclay)

  • Md Amit Hasan

    (Institut des neurosciences Paris-Saclay)

  • Sandra Autran

    (Institut des neurosciences Paris-Saclay)

  • François Laurent

    (Decision and Bayesian Computation
    INRIA)

  • Martin Paul Nawrot

    (University of Cologne)

  • Jean-Baptiste Masson

    (Decision and Bayesian Computation
    INRIA)

  • Tihana Jovanic

    (Institut des neurosciences Paris-Saclay)

Abstract

An animal’s feeding state changes its behavioral priorities and thus influences even nonfeeding-related decisions. How the feeding state information is transmitted to nonfeeding-related circuits and what circuit mechanisms are involved in biasing nonfeeding-related decisions remain open questions. By combining calcium imaging, neuronal manipulations, behavioral analysis and computational modeling, we determined that the competition between different aversive responses to mechanical cues is biased by changes in the feeding state. We found that this effect is achieved by the differential modulation of two different types of reciprocally connected inhibitory neurons promoting opposing actions. This modulation results in a more frequent active type of response and, less frequently, a protective type of response if larvae are fed sugar than when they are fed a balanced diet. Information about the internal state is conveyed to inhibitory neurons through homologs of the vertebrate neuropeptide Y, which is known to be involved in regulating feeding behavior.

Suggested Citation

  • Eloïse Tredern & Dylan Manceau & Alexandre Blanc & Abhijit Parameswaran & Panagiotis Sakagiannis & Chloe Barre & Victoria Sus & Francesca Viscido & Perla Akiki & Md Amit Hasan & Sandra Autran & Franço, 2025. "Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila," Nature Communications, Nature, vol. 16(1), pages 1-24, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61805-y
    DOI: 10.1038/s41467-025-61805-y
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    References listed on IDEAS

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    1. Maxime Lehman & Chloé Barré & Md Amit Hasan & Benjamin Flament & Sandra Autran & Neena Dhiman & Peter Soba & Jean-Baptiste Masson & Tihana Jovanic, 2025. "Neural circuits underlying context-dependent competition between defensive actions in Drosophila larvae," Nature Communications, Nature, vol. 16(1), pages 1-21, December.
    2. Jonathan P. Fadok & Sabine Krabbe & Milica Markovic & Julien Courtin & Chun Xu & Lema Massi & Paolo Botta & Kristine Bylund & Christian Müller & Aleksandar Kovacevic & Philip Tovote & Andreas Lüthi, 2017. "A competitive inhibitory circuit for selection of active and passive fear responses," Nature, Nature, vol. 542(7639), pages 96-100, February.
    3. Tomoko Ohyama & Casey M. Schneider-Mizell & Richard D. Fetter & Javier Valdes Aleman & Romain Franconville & Marta Rivera-Alba & Brett D. Mensh & Kristin M. Branson & Julie H. Simpson & James W. Truma, 2015. "A multilevel multimodal circuit enhances action selection in Drosophila," Nature, Nature, vol. 520(7549), pages 633-639, April.
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