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Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers

Author

Listed:
  • Hannes Vietzen

    (Medical University of Vienna)

  • Laura M. Kühner

    (Medical University of Vienna)

  • Sarah M. Berger

    (Medical University of Vienna)

  • Markus Ponleitner

    (Medical University of Vienna
    Medical University of Vienna)

  • Marianne Graninger

    (Medical University of Vienna)

  • Charlotte Pistorius

    (Lower Austria and Burgenland)

  • Christof Jungbauer

    (Lower Austria and Burgenland
    Paracelsus Medical University)

  • Markus Reindl

    (Medical University of Innsbruck)

  • Henrieke Saucke

    (University Witten/ Herdecke)

  • Franziska Kauth

    (University Witten/ Herdecke)

  • Eva-Maria Wendel

    (Olgahospital)

  • Kevin Rostásy

    (University Witten/ Herdecke)

  • Markus Breu

    (Medical University of Vienna
    Medical University of Vienna)

  • Barbara Kornek

    (Medical University of Vienna
    Medical University of Vienna)

  • Gabriel Bsteh

    (Medical University of Vienna
    Medical University of Vienna)

  • Thomas Berger

    (Medical University of Vienna
    Medical University of Vienna)

  • Paulus Rommer

    (Medical University of Vienna
    Medical University of Vienna)

  • Elisabeth Puchhammer-Stöckl

    (Medical University of Vienna)

Abstract

Multiple sclerosis (MS) is an immune-mediated demyelinating disease. Epstein-Barr virus (EBV) encodes for the EBNA-1381-452 region that induces autoreactive antibody responses, which are likely critically involved in MS pathogenesis. Here we investigate whether these EBNA-1381-452-specific antibodies can serve as a biomarker to identify at-risk individuals for MS. We quantify EBNA-1381-452-specific antibody titers from 324 relapsing-remitting MS patients and 324 matched controls in longitudinal follow-up plasma samples, starting from the individual’s EBV-seroconversion. In MS patients, significantly elevated EBNA-1381-452-specific IgG titers are identified that are increased already as early as nine months after EBV-seroconversion (OR:5.7; 95% CI: 4.1-8.1; P

Suggested Citation

  • Hannes Vietzen & Laura M. Kühner & Sarah M. Berger & Markus Ponleitner & Marianne Graninger & Charlotte Pistorius & Christof Jungbauer & Markus Reindl & Henrieke Saucke & Franziska Kauth & Eva-Maria W, 2025. "Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61751-9
    DOI: 10.1038/s41467-025-61751-9
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    References listed on IDEAS

    as
    1. Tobias V. Lanz & R. Camille Brewer & Peggy P. Ho & Jae-Seung Moon & Kevin M. Jude & Daniel Fernandez & Ricardo A. Fernandes & Alejandro M. Gomez & Gabriel-Stefan Nadj & Christopher M. Bartley & Ryan D, 2022. "Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM," Nature, Nature, vol. 603(7900), pages 321-327, March.
    Full references (including those not matched with items on IDEAS)

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