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Microneedle-based integrated pharmacokinetic and pharmacodynamic evaluation platform for personalized medicine

Author

Listed:
  • Jian Yang

    (Shenzhen Campus of Sun Yat-Sen University
    University of South China)

  • Xia Gong

    (Shenzhen Campus of Sun Yat-Sen University
    Department of Chemical Engineering and Russell Berrie Nanotechnology Institute Technion-Israel Institute of Technology)

  • Ying Zheng

    (Shenzhen Campus of Sun Yat-Sen University)

  • Hong Duan

    (Shenzhen Campus of Sun Yat-Sen University)

  • Shuijin Chen

    (Shenzhen Campus of Sun Yat-Sen University)

  • Tong Wu

    (Shenzhen Campus of Sun Yat-Sen University)

  • Changqing Yi

    (Shenzhen Campus of Sun Yat-Sen University
    Research Institute of Sun Yat-Sen University in Shenzhen)

  • Lelun Jiang

    (Shenzhen Campus of Sun Yat-Sen University)

  • Hossam Haick

    (Department of Chemical Engineering and Russell Berrie Nanotechnology Institute Technion-Israel Institute of Technology)

Abstract

Precision and personalized medicine for disease management necessitates real-time, continuous monitoring of biomarkers and therapeutic drugs to adjust treatment regimens based on individual patient responses. This study introduces a wearable Microneedle-based Continuous Biomarker/Drug Monitoring (MCBM) system, designed for the simultaneous, in vivo pharmacokinetic and pharmacodynamic evaluation for diabetes. Utilizing a dual-sensor microneedle and a layer-by-layer nanoenzyme immobilization strategy, the MCBM system achieves high sensitivity and specificity in measuring glucose and metformin concentrations in skin interstitial fluid (ISF). Seamless integration with a smartphone application enables real-time data analysis and feedback, fostering a pharmacologically informed approach to diabetes management. The MCBM system’s validation and in vivo trials demonstrate its precise monitoring of glucose and metformin, offering a tool for personalized treatment adjustments. Its proven biocompatibility and safety suit long-term usage. This system advances personalized diabetes care, highlighting the move towards wearables that adjust drug dosages in real-time, enhancing precision and personalized medicine.

Suggested Citation

  • Jian Yang & Xia Gong & Ying Zheng & Hong Duan & Shuijin Chen & Tong Wu & Changqing Yi & Lelun Jiang & Hossam Haick, 2025. "Microneedle-based integrated pharmacokinetic and pharmacodynamic evaluation platform for personalized medicine," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61549-9
    DOI: 10.1038/s41467-025-61549-9
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