IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-61504-8.html
   My bibliography  Save this article

Type 1 innate lymphoid cell–immature neutrophil axis suppresses acute tissue inflammation

Author

Listed:
  • Kenshiro Matsuda

    (University of Tsukuba
    University of Tsukuba
    University of Tsukuba
    Harvard University)

  • Natsuki Ide

    (University of Tsukuba
    University of Tsukuba)

  • Yan Xu

    (University of Tsukuba
    University of Tsukuba)

  • Ayana Iijima

    (University of Tsukuba
    University of Tsukuba)

  • Akira Shibuya

    (University of Tsukuba
    University of Tsukuba
    University of Tsukuba)

Abstract

Immature neutrophils (imNeu) are a minor population of circulating neutrophils that migrate from the bone marrow (BM) into the circulation and inflamed tissues during infection, injury, physical stress, and cancer. However, the underlying mechanism of their mobilization from BM and its pathophysiological significance remains incompletely understood. Here, we show that interferon-gamma (IFN-γ) derived from type 1 innate lymphoid cells (ILC1) enhances the migration of imNeu, but not mature neutrophils, from the BM into inflamed liver tissue with ischemia–reperfusion injury and the blood circulation during polymicrobial sepsis in mice. Mechanistically, the scaffold protein Ahnak, which is specifically expressed in imNeu, underpins Smad7 nuclear translocation in response to IFN-γ, thus downregulating C-X-C chemokine receptor 4 expression critical for neutrophil retention in the BM. Furthermore, imNeu produce interleukin-10 to ameliorate tissue inflammation. Our findings thus reveal the ILC1–imNeu axis that protects tissues from acute inflammation due to injury or microbial infection.

Suggested Citation

  • Kenshiro Matsuda & Natsuki Ide & Yan Xu & Ayana Iijima & Akira Shibuya, 2025. "Type 1 innate lymphoid cell–immature neutrophil axis suppresses acute tissue inflammation," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61504-8
    DOI: 10.1038/s41467-025-61504-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-61504-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-61504-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61504-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.