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Genetic risk-dependent brain markers of resilience to childhood Trauma

Author

Listed:
  • Han Lu

    (Fudan University
    Fudan University)

  • Edmund T. Rolls

    (Oxford Centre for Computational Neuroscience
    University of Warwick)

  • Hanjia Liu

    (Fudan University)

  • Dan J. Stein

    (University of Cape Town)

  • Barbara J. Sahakian

    (University of Cambridge
    University of Cambridge)

  • Rebecca Elliott

    (University of Manchester)

  • Tianye Jia

    (Fudan University)

  • Chao Xie

    (Fudan University)

  • Shitong Xiang

    (Fudan University)

  • Nan Wang

    (Fudan University)

  • Tobias Banaschewski

    (Heidelberg University)

  • Arun L. W. Bokde

    (Trinity College Dublin)

  • Sylvane Desrivières

    (King’s College London)

  • Herta Flor

    (Heidelberg University
    University of Mannheim)

  • Antoine Grigis

    (Université Paris-Saclay)

  • Hugh Garavan

    (University of Vermont)

  • Andreas Heinz

    (and Berlin Institute of Health)

  • Rüdiger Brühl

    (Physikalisch-Technische Bundesanstalt (PTB))

  • Jean-Luc Martinot

    (CNRS; Centre Borelli)

  • Marie-Laure Paillère Martinot

    (CNRS; Centre Borelli
    Pitié-Salpêtrière Hospital)

  • Eric Artiges

    (CNRS; Centre Borelli
    EPS Barthélémy Durand)

  • Frauke Nees

    (Heidelberg University
    Kiel University)

  • Dimitri Papadopoulos Orfanos

    (University of Mannheim)

  • Herve Lemaitre

    (Université Paris-Saclay
    Université de Bordeaux)

  • Luise Poustka

    (University Hospital Heidelberg)

  • Sarah Hohmann

    (Heidelberg University)

  • Nathalie Holz

    (Heidelberg University)

  • Juliane H. Fröhner

    (Technische Universität Dresden)

  • Michael N. Smolka

    (Technische Universität Dresden)

  • Nilakshi Vaidya

    (Charité University Medicine Berlin)

  • Henrik Walter

    (and Berlin Institute of Health)

  • Robert Whelan

    (Trinity College Dublin)

  • Gunter Schumann

    (Technische Universität Dresden
    Fudan University)

  • Jianfeng Feng

    (University of Warwick
    Fudan University)

  • Qiang Luo

    (Fudan University
    Fudan University
    Shanghai Jiao Tong University School of Medicine
    Shanghai Research Center of Acupuncture & Meridian)

Abstract

Resilience to developing emotional disorders is critical for adolescent mental health, especially following childhood trauma. Yet, brain markers of resilience remain poorly understood. By analyzing brain responses to angry faces in a large-scale longitudinal adolescent cohort (IMAGEN), we identified two functional networks located in the orbitofrontal and occipital regions. In girls with high genetic risks for depression, higher orbitofrontal-related network activation was associated with a reduced impact of childhood trauma on emotional symptoms at age 19, whereas in those with low genetic risks, lower occipital-related network activation had a similar association. These findings reveal genetic risk-dependent brain markers of resilience (GRBMR). Longitudinally, the orbitofrontal-related GRBMR predicted subsequent emotional disorders in late adolescence, which were generalizable to an independent prospective cohort (ABCD). These findings demonstrate that high polygenic depression risk relates to activations in the orbitofrontal network and to resilience, with implications for biomarkers and treatment.

Suggested Citation

  • Han Lu & Edmund T. Rolls & Hanjia Liu & Dan J. Stein & Barbara J. Sahakian & Rebecca Elliott & Tianye Jia & Chao Xie & Shitong Xiang & Nan Wang & Tobias Banaschewski & Arun L. W. Bokde & Sylvane Desri, 2025. "Genetic risk-dependent brain markers of resilience to childhood Trauma," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61471-0
    DOI: 10.1038/s41467-025-61471-0
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    References listed on IDEAS

    as
    1. Reinoud Kaldewaij & Saskia B. J. Koch & Mahur M. Hashemi & Wei Zhang & Floris Klumpers & Karin Roelofs, 2021. "Anterior prefrontal brain activity during emotion control predicts resilience to post-traumatic stress symptoms," Nature Human Behaviour, Nature, vol. 5(8), pages 1055-1064, August.
    2. Shaoling Peng & Pengfei Xu & Yaya Jiang & Gaolang Gong, 2022. "Activation network mapping for integration of heterogeneous fMRI findings," Nature Human Behaviour, Nature, vol. 6(10), pages 1417-1429, October.
    3. Lindsay Willmore & Courtney Cameron & John Yang & Ilana B. Witten & Annegret L. Falkner, 2022. "Behavioural and dopaminergic signatures of resilience," Nature, Nature, vol. 611(7934), pages 124-132, November.
    Full references (including those not matched with items on IDEAS)

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