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ER-related E2-E3 ubiquitin enzyme pair regulates ethylene response by modulating the turnover of ethylene receptors

Author

Listed:
  • Qingcui Zhao

    (China Agricultural University)

  • Xiaofeng Zhou

    (China Agricultural University)

  • Qian Chen

    (Chinese Academy of Sciences
    China Agricultural University)

  • Ruoyun Yang

    (China Agricultural University)

  • Yonghong Li

    (Shenzhen Polytechnic University)

  • Jiaxin Zhao

    (China Agricultural University)

  • Xijia Fu

    (China Agricultural University)

  • Yan Lin

    (China Agricultural University)

  • Yuming Liu

    (China Agricultural University)

  • Liangjun Zhao

    (China Agricultural University)

  • Cai-Zhong Jiang

    (Agricultural Research Service
    University of California Davis)

  • Su-Sheng Gan

    (Cornell University)

  • Qi Xie

    (Chinese Academy of Sciences)

  • Junping Gao

    (China Agricultural University)

  • Nan Ma

    (China Agricultural University)

Abstract

Gaseous phytohormone ethylene regulates various aspects of plant development. Ethylene is perceived by ER membrane-localized receptors, which are inactivated upon binding with ethylene molecules, thereby initiating ethylene signal transduction. Here, we report that a novel E3 ligase RING finger for Ethylene receptor Degradation (RED) and its E2 partner UBC32 ubiquitinate ethylene-bound receptors for degradation through an ER associated degradation (ERAD) pathway in both Rosa hybrida and Solanum lycopersicum. The depletion of RED or UBC32 leads to hypersensitivity to ethylene, which is manifested as premature leaf abscission and petal shedding in roses, as well as the dwarf plants and accelerated fruit ripening in tomatoes. Disruption of the conserved ethylene binding site of receptors prevents RED-mediated degradation of the receptors. Our study discovers an ERAD branch that facilitates the ethylene-induced degradation of receptors, and provides insights into how the plant’s response to ethylene can be controlled by modulating the turnover of ethylene receptors.

Suggested Citation

  • Qingcui Zhao & Xiaofeng Zhou & Qian Chen & Ruoyun Yang & Yonghong Li & Jiaxin Zhao & Xijia Fu & Yan Lin & Yuming Liu & Liangjun Zhao & Cai-Zhong Jiang & Su-Sheng Gan & Qi Xie & Junping Gao & Nan Ma, 2025. "ER-related E2-E3 ubiquitin enzyme pair regulates ethylene response by modulating the turnover of ethylene receptors," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61066-9
    DOI: 10.1038/s41467-025-61066-9
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    References listed on IDEAS

    as
    1. Xin-Kai Li & Yi-Hua Huang & Rui Zhao & Wu-Qiang Cao & Long Lu & Jia-Qi Han & Yang Zhou & Xun Zhang & Wen-Ai Wu & Jian-Jun Tao & Wei Wei & Wan-Ke Zhang & Shou-Yi Chen & Biao Ma & He Zhao & Cui-Cui Yin , 2024. "Membrane protein MHZ3 regulates the on-off switch of ethylene signaling in rice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Jacob Pollier & Tessa Moses & Miguel González-Guzmán & Nathan De Geyter & Saskia Lippens & Robin Vanden Bossche & Peter Marhavý & Anna Kremer & Kris Morreel & Christopher J. Guérin & Aldo Tava & Wiesl, 2013. "The protein quality control system manages plant defence compound synthesis," Nature, Nature, vol. 504(7478), pages 148-152, December.
    3. Kevin L.-C. Wang & Hitoshi Yoshida & Claire Lurin & Joseph R. Ecker, 2004. "Regulation of ethylene gas biosynthesis by the Arabidopsis ETO1 protein," Nature, Nature, vol. 428(6986), pages 945-950, April.
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