IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-61046-z.html
   My bibliography  Save this article

A high-fiber diet mimics aging-related signatures of caloric restriction in mammals

Author

Listed:
  • Fangchao Hu

    (Shanghai Jiao Tong University)

  • Lu Yu

    (Shanghai Jiao Tong University)

  • Xingyu Tu

    (Shanghai Jiao Tong University)

  • Rong Huang

    (Shanghai Jiao Tong University)

  • Xinyue Yan

    (Shanghai Jiao Tong University)

  • Liping Wang

    (Shanghai Jiao Tong University)

  • Yang Wei

    (Shanghai Jiao Tong University)

  • Xinlin Wei

    (Shanghai Jiao Tong University)

  • Ziyun Wu

    (Shanghai Jiao Tong University)

Abstract

Caloric restriction (CR) delays aging-related hallmarks in various organisms by slowing growth and development while enhancing metabolic homeostasis. However, desirable diets that harness the metabolic benefits of CR without imposing food intake restrictions remain elusive. Here we evaluated the effects of a high-fiber diet we developed, in which 30% of the macronutrients in a standard diet are replaced with indigestible cellulose, compared to a CR control consisting of a nighttime-2h-restricted feeding regimen. Our findings show that the 2h-restricted feeding triggered a robust systemic response associated with the anti-aging benefits typically observed with CR. Intriguingly, the high-fiber diet did not reduce food intake but mimicked the aging-related signatures of CR in male mice from young to old age. These results indicate that the high-fiber diet confers promising benefits for metabolic homeostasis and represents a valuable candidate for further health and aging studies.

Suggested Citation

  • Fangchao Hu & Lu Yu & Xingyu Tu & Rong Huang & Xinyue Yan & Liping Wang & Yang Wei & Xinlin Wei & Ziyun Wu, 2025. "A high-fiber diet mimics aging-related signatures of caloric restriction in mammals," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61046-z
    DOI: 10.1038/s41467-025-61046-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-61046-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-61046-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Cynthia J. Kenyon, 2010. "The genetics of ageing," Nature, Nature, vol. 464(7288), pages 504-512, March.
    2. Jane L. Hurst & Caroline E. Payne & Charlotte M. Nevison & Amr D. Marie & Richard E. Humphries & Duncan H. L. Robertson & Andrea Cavaggioni & Robert J. Beynon, 2001. "Individual recognition in mice mediated by major urinary proteins," Nature, Nature, vol. 414(6864), pages 631-634, December.
    3. Collin Y. Ewald & Jess N. Landis & Jess Porter Abate & Coleen T. Murphy & T. Keith Blackwell, 2015. "Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity," Nature, Nature, vol. 519(7541), pages 97-101, March.
    4. Cynthia J. Kenyon, 2010. "Erratum: The genetics of ageing," Nature, Nature, vol. 467(7315), pages 622-622, September.
    5. Simon C. Johnson & Peter S. Rabinovitch & Matt Kaeberlein, 2013. "mTOR is a key modulator of ageing and age-related disease," Nature, Nature, vol. 493(7432), pages 338-345, January.
    6. Ryo Yamamoto & Ryan Chung & Juan Manuel Vazquez & Huanjie Sheng & Philippa L. Steinberg & Nilah M. Ioannidis & Peter H. Sudmant, 2022. "Tissue-specific impacts of aging and genetics on gene expression patterns in humans," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    7. Kan Xie & Frauke Neff & Astrid Markert & Jan Rozman & Juan Antonio Aguilar-Pimentel & Oana Veronica Amarie & Lore Becker & Robert Brommage & Lillian Garrett & Kristin S. Henzel & Sabine M. Hölter & Di, 2017. "Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice," Nature Communications, Nature, vol. 8(1), pages 1-19, December.
    8. Joseph A. Baur & Kevin J. Pearson & Nathan L. Price & Hamish A. Jamieson & Carles Lerin & Avash Kalra & Vinayakumar V. Prabhu & Joanne S. Allard & Guillermo Lopez-Lluch & Kaitlyn Lewis & Paul J. Piste, 2006. "Resveratrol improves health and survival of mice on a high-calorie diet," Nature, Nature, vol. 444(7117), pages 337-342, November.
    9. David E. Harrison & Randy Strong & Zelton Dave Sharp & James F. Nelson & Clinton M. Astle & Kevin Flurkey & Nancy L. Nadon & J. Erby Wilkinson & Krystyna Frenkel & Christy S. Carter & Marco Pahor & Ma, 2009. "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice," Nature, Nature, vol. 460(7253), pages 392-395, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yan-Ping Zhang & Wen-Hong Zhang & Pan Zhang & Qi Li & Yue Sun & Jia-Wen Wang & Shaobing O. Zhang & Tao Cai & Cheng Zhan & Meng-Qiu Dong, 2022. "Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Cyril Statzer & Jin Meng & Richard Venz & Monet Bland & Stacey Robida-Stubbs & Krina Patel & Dunja Petrovic & Raffaella Emsley & Pengpeng Liu & Ianessa Morantte & Cole Haynes & William B. Mair & Alban, 2022. "ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Kan Xie & Helmut Fuchs & Enzo Scifo & Dan Liu & Ahmad Aziz & Juan Antonio Aguilar-Pimentel & Oana Veronica Amarie & Lore Becker & Patricia da Silva-Buttkus & Julia Calzada-Wack & Yi-Li Cho & Yushuang , 2022. "Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice," Nature Communications, Nature, vol. 13(1), pages 1-29, December.
    4. Jin-Hyuck Jeong & Jun-Seok Han & Youngae Jung & Seung-Min Lee & So-Hyun Park & Mooncheol Park & Min-Gi Shin & Nami Kim & Mi Sun Kang & Seokho Kim & Kwang-Pyo Lee & Ki-Sun Kwon & Chun-A. Kim & Yong Ryo, 2023. "A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. repec:plo:pcbi00:1000820 is not listed on IDEAS
    6. Alan Kavšek & Jérôme Salignon & Lluís Millan-Ariño & Patryk Marcinkowski & Ilke Sen & Christian G. Riedel, 2025. "LIN-39 is a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin signaling," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    7. Xueqing Wang & Quanlong Jiang & Hongdao Zhang & Zhidong He & Yuanyuan Song & Yifan Chen & Na Tang & Yifei Zhou & Yiping Li & Adam Antebi & Ligang Wu & Jing-Dong J. Han & Yidong Shen, 2024. "Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    8. Harper S. Kim & Danitra J. Parker & Madison M. Hardiman & Erin Munkácsy & Nisi Jiang & Aric N. Rogers & Yidong Bai & Colin Brent & James A. Mobley & Steven N. Austad & Andrew M. Pickering, 2023. "Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    9. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.
    10. Huiru Bai & Xiaoqin Liu & Meizhen Lin & Yuan Meng & Ruolan Tang & Yajing Guo & Nan Li & Michael F. Clarke & Shang Cai, 2024. "Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    11. Jiangbo Song & Zhiquan Li & Lei Zhou & Xin Chen & Wei Qi Guinevere Sew & Héctor Herranz & Zilu Ye & Jesper Velgaard Olsen & Yuan Li & Marianne Nygaard & Kaare Christensen & Xiaoling Tong & Vilhelm A. , 2024. "FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    12. Kejun Ying & José P. Castro & Anastasia V. Shindyapina & Alexander Tyshkovskiy & Mahdi Moqri & Ludger J. E. Goeminne & Sofiya Milman & Zhengdong D. Zhang & Nir Barzilai & Vadim N. Gladyshev, 2024. "Depletion of loss-of-function germline mutations in centenarians reveals longevity genes," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    13. Caroline Beaudoin-Chabot & Lei Wang & Cenk Celik & Aishah Tul-Firdaus Abdul Khalid & Subhash Thalappilly & Shiyi Xu & Jhee Hong Koh & Venus Wen Xuan Lim & Ann Don Low & Guillaume Thibault, 2022. "The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    14. Eirini Lionaki & Ilias Gkikas & Ioanna Daskalaki & Maria-Konstantina Ioannidi & Maria I. Klapa & Nektarios Tavernarakis, 2022. "Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    15. Zhifei Zhang & Haiyan Yang & Lei Fang & Guangrong Zhao & Jun Xiang & Jialin C. Zheng & Zhao Qin, 2024. "DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    16. Qucheng Deng & Yongping Wei & Lijuan Chen & Wei Liang & Jijun Du & Yuling Tan & Yinjun Zhao, 2019. "Relationship between Air Pollution and Regional Longevity in Guangxi, China," IJERPH, MDPI, vol. 16(19), pages 1-12, October.
    17. Carlos A. Vergani-Junior & Raíssa De P. Moro & Silas Pinto & Evandro A. De-Souza & Henrique Camara & Deisi L. Braga & Guilherme Tonon-da-Silva & Thiago L. Knittel & Gabriel P. Ruiz & Raissa G. Ludwig , 2024. "An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    18. Mark G Sterken & L Basten Snoek & Kobus J Bosman & Jikke Daamen & Joost A G Riksen & Jaap Bakker & Gorben P Pijlman & Jan E Kammenga, 2014. "A Heritable Antiviral RNAi Response Limits Orsay Virus Infection in Caenorhabditis elegans N2," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    19. Marcin Pilarczyk & Mehdi Fazel-Najafabadi & Michal Kouril & Behrouz Shamsaei & Juozas Vasiliauskas & Wen Niu & Naim Mahi & Lixia Zhang & Nicholas A. Clark & Yan Ren & Shana White & Rashid Karim & Huan, 2022. "Connecting omics signatures and revealing biological mechanisms with iLINCS," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    20. Edouard Debonneuil & Anne Eyraud-Loisel & Frédéric Planchet, 2018. "Can Pension Funds Partially Manage Longevity Risk by Investing in a Longevity Megafund?," Risks, MDPI, vol. 6(3), pages 1-27, July.
    21. Qucheng Deng & Lijuan Chen & Yongping Wei & Yonghua Li & Xuerong Han & Wei Liang & Yinjun Zhao & Xiaofei Wang & Juan Yin, 2018. "Understanding the Association between Environmental Factors and Longevity in Hechi, China: A Drinking Water and Soil Quality Perspective," IJERPH, MDPI, vol. 15(10), pages 1-17, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61046-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.