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A high-fiber diet mimics aging-related signatures of caloric restriction in mammals

Author

Listed:
  • Fangchao Hu

    (Shanghai Jiao Tong University)

  • Lu Yu

    (Shanghai Jiao Tong University)

  • Xingyu Tu

    (Shanghai Jiao Tong University)

  • Rong Huang

    (Shanghai Jiao Tong University)

  • Xinyue Yan

    (Shanghai Jiao Tong University)

  • Liping Wang

    (Shanghai Jiao Tong University)

  • Yang Wei

    (Shanghai Jiao Tong University)

  • Xinlin Wei

    (Shanghai Jiao Tong University)

  • Ziyun Wu

    (Shanghai Jiao Tong University)

Abstract

Caloric restriction (CR) delays aging-related hallmarks in various organisms by slowing growth and development while enhancing metabolic homeostasis. However, desirable diets that harness the metabolic benefits of CR without imposing food intake restrictions remain elusive. Here we evaluated the effects of a high-fiber diet we developed, in which 30% of the macronutrients in a standard diet are replaced with indigestible cellulose, compared to a CR control consisting of a nighttime-2h-restricted feeding regimen. Our findings show that the 2h-restricted feeding triggered a robust systemic response associated with the anti-aging benefits typically observed with CR. Intriguingly, the high-fiber diet did not reduce food intake but mimicked the aging-related signatures of CR in male mice from young to old age. These results indicate that the high-fiber diet confers promising benefits for metabolic homeostasis and represents a valuable candidate for further health and aging studies.

Suggested Citation

  • Fangchao Hu & Lu Yu & Xingyu Tu & Rong Huang & Xinyue Yan & Liping Wang & Yang Wei & Xinlin Wei & Ziyun Wu, 2025. "A high-fiber diet mimics aging-related signatures of caloric restriction in mammals," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61046-z
    DOI: 10.1038/s41467-025-61046-z
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