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Chiroptical switching and strong circularly polarized luminescence in peptide supramolecular assemblies

Author

Listed:
  • Xin Li

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Jinan Microecological Biomedicine Shandong Laboratory)

  • Qingquan Han

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xianbao Li

    (National Center for Nanoscience and Technology)

  • Rui Li

    (Chinese Academy of Sciences)

  • Anhe Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Sen Liang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yutao Sang

    (Fudan University)

  • Jieling Li

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yajie Tian

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yang Yang

    (National Center for Nanoscience and Technology)

  • Qi Li

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Shuo Bai

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Junbai Li

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

Abstract

Peptide-based materials offer unique advantages for constructing supramolecular chiral systems due to their bioactivity and intrinsic chirality. However, precise control over the expression, transfer, and amplification of chirality from the molecular to supramolecular level remains a significant challenge in developing high-performance chiral materials. In this study, we demonstrate that achiral anions regulate hydrogen bonding interactions in dipeptide assembly, leading to the formation of chiral microrolls composed of two-dimensional nanosheets. These microrolls exhibit pH-dependent chiroptical switching and intense circularly polarized luminescence with a dissymmetry factor (|glum|) of 0.062. Furthermore, the chiral ultraviolet emission from these microrolls enables enantioselective polymerization of diacetylene, offering potential applications in chiral catalysis. These findings enhance our understanding of chirality modulation in biomolecular assemblies and provide a pathway toward the development of high-performance chiral biomaterials.

Suggested Citation

  • Xin Li & Qingquan Han & Xianbao Li & Rui Li & Anhe Wang & Sen Liang & Yutao Sang & Jieling Li & Yajie Tian & Yang Yang & Qi Li & Shuo Bai & Junbai Li, 2025. "Chiroptical switching and strong circularly polarized luminescence in peptide supramolecular assemblies," Nature Communications, Nature, vol. 16(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-61007-6
    DOI: 10.1038/s41467-025-61007-6
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    References listed on IDEAS

    as
    1. Hye-Eun Lee & Ryeong Myeong Kim & Hyo-Yong Ahn & Yoon Young Lee & Gi Hyun Byun & Sang Won Im & Jungho Mun & Junsuk Rho & Ki Tae Nam, 2020. "Cysteine-encoded chirality evolution in plasmonic rhombic dodecahedral gold nanoparticles," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. Kai Qi & Hao Qi & Muhan Wang & Xiaoyue Ma & Yan Wang & Qiang Yao & Wenliang Liu & Yurong Zhao & Jiqian Wang & Yuefei Wang & Wei Qi & Jun Zhang & Jian R. Lu & Hai Xu, 2024. "Chiral inversion induced by aromatic interactions in short peptide assembly," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
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