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A constricted mitochondrial morphology formed during respiration

Author

Listed:
  • Manish K. Singh

    (Institut de Biologie Physico-Chimique
    Imaging and Modeling Unit)

  • Laetitia Cavellini

    (Institut de Biologie Physico-Chimique)

  • Maria Angeles Morcillo-Parra

    (Institut de Biologie Physico-Chimique)

  • Christina Kunz

    (Department of Structural Biology)

  • Mickaël Lelek

    (Imaging and Modeling Unit)

  • Perrine Bomme

    (Université Paris Cité)

  • Aurélia Barascu

    (Institut de Biologie Physico-Chimique)

  • Cynthia Alsayyah

    (Institut de Biologie Physico-Chimique
    Saarland University)

  • Maria Teresa Teixeira

    (Institut de Biologie Physico-Chimique)

  • Naïma Belgareh-Touzé

    (Institut de Biologie Physico-Chimique)

  • Adeline Mallet

    (Université Paris Cité)

  • Lea Dietrich

    (Department of Structural Biology)

  • Christophe Zimmer

    (Imaging and Modeling Unit
    University of Würzburg)

  • Mickael M. Cohen

    (Institut de Biologie Physico-Chimique)

Abstract

Mitochondria assemble in a dynamic tubular network. Their morphology is governed by mitochondrial fusion and fission, which regulate most mitochondrial functions including oxidative phosphorylation. Yet, the link between mitochondrial morphology and respiratgion remains unclear. Here, we uncover a mitochondrial morphology dedicated to respiratory growth of Saccharomyces cerevisiae, which we refer to as “Ringo”. The Ringo morphology is characterized by stable constrictions of mitochondrial tubules. Ringo constrictions are mediated by the yeast dynamin Dnm1 and, unlike mitochondrial fission, occur in the absence of contacts with the endoplasmic reticulum. Our data show that blocking formation of the Ringo morphology correlates with decreased respiration, decreased expression of OXPHOS subunits and perturbed mitochondrial DNA distribution. These results open important perspectives about the link between mitochondrial form and function.

Suggested Citation

  • Manish K. Singh & Laetitia Cavellini & Maria Angeles Morcillo-Parra & Christina Kunz & Mickaël Lelek & Perrine Bomme & Aurélia Barascu & Cynthia Alsayyah & Maria Teresa Teixeira & Naïma Belgareh-Touzé, 2025. "A constricted mitochondrial morphology formed during respiration," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60658-9
    DOI: 10.1038/s41467-025-60658-9
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    References listed on IDEAS

    as
    1. Cynthia Alsayyah & Manish K Singh & Maria Angeles Morcillo-Parra & Laetitia Cavellini & Nadav Shai & Christine Schmitt & Maya Schuldiner & Einat Zalckvar & Adeline Mallet & Naïma Belgareh-Touzé & Chri, 2024. "Mitofusin-mediated contacts between mitochondria and peroxisomes regulate mitochondrial fusion," PLOS Biology, Public Library of Science, vol. 22(4), pages 1-37, April.
    2. Bongki Cho & Hyo Min Cho & Youhwa Jo & Hee Dae Kim & Myungjae Song & Cheil Moon & Hyongbum Kim & Kyungjin Kim & Hiromi Sesaki & Im Joo Rhyu & Hyun Kim & Woong Sun, 2017. "Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division," Nature Communications, Nature, vol. 8(1), pages 1-17, August.
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