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An mRNA vaccine encoding five conserved Group A Streptococcus antigens

Author

Listed:
  • Nichaela Harbison-Price

    (The University of Queensland)

  • Ismail Sebina

    (The University of Queensland)

  • Rhiannon A. Bolton

    (The University of Queensland)

  • Meredith Finn

    (325 Binney Street)

  • Amanda J. Cork

    (The University of Queensland)

  • Isabel G. Courtney

    (The University of Queensland)

  • Steven Hancock

    (The University of Queensland)

  • Ruby Pelingon

    (The University of Queensland)

  • Johanna Richter

    (The University of Queensland)

  • Olivia Ericsson

    (325 Binney Street)

  • Shannon Green

    (325 Binney Street)

  • Celeste Cuellar

    (325 Binney Street)

  • Laura Davis

    (The University of Queensland)

  • Brody Pullinger

    (The University of Queensland)

  • Jack Na

    (The University of Queensland)

  • Gayathiri Elangovan

    (The University of Queensland)

  • David M. P. Oliveira

    (The University of Queensland)

  • Bodie F. Curren

    (The University of Queensland)

  • Nia Bickham

    (The University of Queensland)

  • Miguel Aguirre

    (The University of Queensland)

  • Christina Dold

    (325 Binney Street)

  • Stephan Brouwer

    (The University of Queensland)

  • Obadiah Plante

    (325 Binney Street)

  • Gabrielle T. Belz

    (The University of Queensland)

  • Mark J. Walker

    (The University of Queensland)

Abstract

A commercial vaccine to address the high global burden of Group A Streptococcus (GAS) disease is an urgent and unmet medical need. Messenger RNA (mRNA) lipid-nanoparticle (LNP) vaccines represent a largely untapped platform for targeting bacterial pathogens. Here, we evaluate the immunogenicity and preclinical efficacy of a multicomponent mRNA-LNP vaccine formulation based on the GAS vaccine, Combo#5. Combo#5 mRNA-LNP antigens confer protection from infection in mouse intraperitoneal and subcutaneous challenge models. Combo#5 mRNA-LNP vaccination generates significantly increased frequencies and numbers of effector type CD4+ and CD8 + T cells in the spleen, enhances T follicular helper cells, germinal center B cells and memory B cells in the spleen and draining lymph nodes, and boosts the production of antigen-specific antibodies. These findings demonstrate the potential of the mRNA-LNP platform for the development of vaccines against bacterial pathogens.

Suggested Citation

  • Nichaela Harbison-Price & Ismail Sebina & Rhiannon A. Bolton & Meredith Finn & Amanda J. Cork & Isabel G. Courtney & Steven Hancock & Ruby Pelingon & Johanna Richter & Olivia Ericsson & Shannon Green , 2025. "An mRNA vaccine encoding five conserved Group A Streptococcus antigens," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60580-0
    DOI: 10.1038/s41467-025-60580-0
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