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Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function

Author

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  • Xinxiang You

    (University of Science and Technology of China
    University of Science and Technology of China)

  • Zetao Fan

    (University of Science and Technology of China)

  • Hongli Zhang

    (University of Science and Technology of China)

  • Zhibo Xie

    (Chinese Academy of Sciences)

  • Chengen Li

    (University of Science and Technology of China)

  • Huaqiao Gui

    (Chinese Academy of Sciences)

  • Gang Zou

    (University of Science and Technology of China)

  • Qiwen Zhan

    (University of Shanghai for Science and Technology)

  • Jianguo Liu

    (Chinese Academy of Sciences)

  • Xu Liu

    (Zhejiang University)

  • Douguo Zhang

    (University of Science and Technology of China
    University of Science and Technology of China)

Abstract

Label-free optical imaging and sensing of single nanoparticles are vital for fundamental research, disease diagnosis, and nanomaterial studies. Surface plasmon resonance microscopy (SPRM) is a label-free detection technology which is widely used in the detection of single nanoparticles. However, conventional SPRM suffers from poor spatial resolution, a limited field-of-view, system complexity, and high operating costs. In this study, we introduce a compact, low-cost, and large field-of-view chip-based plasmonic scattering microscopy (Chip-PSM). Compared with SPRM, Chip-PSM retains high detection sensitivity and in situ label-free analysis capability, while offering a larger field-of-view, an isotropic point-spread-function and higher spatial resolution. With these advantages, Chip-PSM enables detecting and imaging dielectric nanoparticles, gold nanoparticles, and biological samples. Additionally, the hygroscopic growth dynamics of aerosol nanoparticles and the chemical reactions occurring on nanocrystals are successfully characterized via Chip-PSM. We anticipate that the proposed Chip-PSM will have broad applications across many scientific fields, including physics, chemistry, and atmospheric sciences.

Suggested Citation

  • Xinxiang You & Zetao Fan & Hongli Zhang & Zhibo Xie & Chengen Li & Huaqiao Gui & Gang Zou & Qiwen Zhan & Jianguo Liu & Xu Liu & Douguo Zhang, 2025. "Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60460-7
    DOI: 10.1038/s41467-025-60460-7
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    References listed on IDEAS

    as
    1. Yang Liu & Mingchuan Huang & Qiankun Chen & Douguo Zhang, 2022. "Single planar photonic chip with tailored angular transmission for multiple-order analog spatial differentiator," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Christina J. Williamson & Agnieszka Kupc & Duncan Axisa & Kelsey R. Bilsback & ThaoPaul Bui & Pedro Campuzano-Jost & Maximilian Dollner & Karl D. Froyd & Anna L. Hodshire & Jose L. Jimenez & John K. K, 2019. "A large source of cloud condensation nuclei from new particle formation in the tropics," Nature, Nature, vol. 574(7778), pages 399-403, October.
    3. Yan Kuai & Junxue Chen & Zetao Fan & Gang Zou & Joseph. R. Lakowicz & Douguo Zhang, 2021. "Planar photonic chips with tailored angular transmission for high-contrast-imaging devices," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    4. Pengfei Zhang & Lei Zhou & Rui Wang & Xinyu Zhou & Jiapei Jiang & Zijian Wan & Shaopeng Wang, 2022. "Evanescent scattering imaging of single protein binding kinetics and DNA conformation changes," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Nareg Ohannesian & Ibrahim Misbah & Steven H. Lin & Wei-Chuan Shih, 2020. "Plasmonic nano-aperture label-free imaging (PANORAMA)," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    6. Gang Wu & Chen Qian & Wen-Li Lv & Xiaona Zhao & Xian-Wei Liu, 2023. "Dynamic imaging of interfacial electrochemistry on single Ag nanowires by azimuth-modulated plasmonic scattering interferometry," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
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