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Cytoreductive surgery and hyperthermic intrathoracic chemotherapy in thymic epithelial tumors with pleural spread or recurrence: a prospective, single-arm, phase II study

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  • Shuai Wang

    (Fudan University
    Fudan University)

  • Xinyu Yang

    (Fudan University
    Fudan University)

  • Jiahao Jiang

    (Fudan University
    Fudan University)

  • Fei Liang

    (Fudan University)

  • Yuansheng Zheng

    (Fudan University
    Fudan University)

  • Yongqiang Ao

    (Fudan University
    Fudan University)

  • Jian Gao

    (Fudan University
    Fudan University)

  • Hao Wang

    (Fudan University
    Fudan University)

  • Lijie Tan

    (Fudan University
    Fudan University)

  • Jianyong Ding

    (Fudan University
    Fudan University)

Abstract

Pleural spread or recurrence of thymic epithelial tumors (TETs) is a tricky puzzle in the clinic and there is currently no recognized effective treatment. This trial evaluated the safety and efficacy of cytoreductive surgery and hyperthermic intrathoracic chemotherapy (S-HITOC) for TETs with pleural spread or recurrence. Here, we reported short-term outcomes of enrolled 45 patients receiving S-HITOC with 25 mg/m2 doxorubicin and 50 mg/m2 cisplatin. The pleural tumor index (PTI) has been proposed for evaluating pleural tumor burden. Treatment-related adverse events of grade ≥3 occurred in eight (17.8%) patients. The pain Visual analog scale (VAS) score was 5.4 ± 1.9 on the 1st day after treatment and was similar to that at baseline level on the 7th day after treatment (p = 0.218). There was no significant difference in the quality of life score (p = 0.676) between baseline and the 60th day after treatment. The estimated 2-year PFS and OS rates were 82.8% and 100.0%, respectively. Subgroup analyses revealed that patients with PTI scores >10 had worse PFS than those with PTI scores ≤10 (p

Suggested Citation

  • Shuai Wang & Xinyu Yang & Jiahao Jiang & Fei Liang & Yuansheng Zheng & Yongqiang Ao & Jian Gao & Hao Wang & Lijie Tan & Jianyong Ding, 2025. "Cytoreductive surgery and hyperthermic intrathoracic chemotherapy in thymic epithelial tumors with pleural spread or recurrence: a prospective, single-arm, phase II study," Nature Communications, Nature, vol. 16(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60386-0
    DOI: 10.1038/s41467-025-60386-0
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