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Tissue-agnostic cancer therapies: promise, reality, and the path forward

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  • Vivek Subbiah

    (Sarah Cannon Research Institute)

Abstract

Tissue-agnostic cancer therapies promise to revolutionize oncology by targeting molecular drivers. Sledge et al.’s study of nearly 300,000 tumors found 21.5% with tissue-agnostic indications. Despite nine FDA approvals, real-world implementation challenges persist. Progress depends on universal genomic testing, an oncogenomic-savvy workforce, innovative trials, updated regulations, and real-world evidence to maximize potential.

Suggested Citation

  • Vivek Subbiah, 2025. "Tissue-agnostic cancer therapies: promise, reality, and the path forward," Nature Communications, Nature, vol. 16(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60369-1
    DOI: 10.1038/s41467-025-60369-1
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    References listed on IDEAS

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    1. Fabrice André & Elie Rassy & Aurélien Marabelle & Stefan Michiels & Benjamin Besse, 2024. "Forget lung, breast or prostate cancer: why tumour naming needs to change," Nature, Nature, vol. 626(7997), pages 26-29, February.
    2. George W. Sledge & Takayuki Yoshino & Joanne Xiu & Anthony Helmstetter & Jennifer R. Ribeiro & Sergey Klimov & Brady Gilg & JJ Gao & Jeff Elton & Matthew J. Oberley & Milan Radovich & Jim Abraham & Da, 2025. "Real-world evidence provides clinical insights into tissue-agnostic therapeutic approvals," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
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